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Open AccessArticle

Self-Reported Exposure to ETS (Environmental Tobacco Smoke), Urinary Cotinine, and Oxidative Stress Parameters in Pregnant Women—The Pilot Study

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Institute of Hygiene, Faculty of Medicine, Comenius University, 81499 Bratislava, Slovakia
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Institute of Medical Chemistry, Biochemistry and Clinical Biochemistry, Faculty of Medicine, Comenius University, 81499 Bratislava, Slovakia
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Institute of Physiotherapy, Balneology and Medical Rehabilitation, University of Ss. Cyril and Methodius in Trnava, 91701 Trnava, Slovakia
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Department of Pediatrics, New York University, New York, NY 10016, USA
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Division of Biomedical Physics, Department of Nuclear Physics and Biophysics, Faculty of Mathematics, Physics and Informatics, Comenius University, 81499 Bratislava, Slovakia
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IInd Gynecology and Obstetrics Clinic, Faculty of Medicine, Comenius University, 81499 Bratislava, Slovakia
*
Author to whom correspondence should be addressed.
Int. J. Environ. Res. Public Health 2019, 16(9), 1656; https://doi.org/10.3390/ijerph16091656
Received: 14 March 2019 / Revised: 22 April 2019 / Accepted: 9 May 2019 / Published: 13 May 2019
(This article belongs to the Special Issue Maternal and Child Environmental Health and Disease)
Background: Exposure to ETS (environmental tobacco smoke) is one of the most toxic environmental exposures. Objective: To investigate the association of ETS with physiological, biochemical, and psychological indicators, as well as with urine antioxidant capacity (AC) and oxidative damage to lipids in a pilot sample of healthy pregnant women. Methods: Exposure to ETS was investigated via a validated questionnaire, and urine cotinine and the marker of oxidative damage to lipids via 8-isoprostane concentrations using an ELISA kit. Urine AC was determined by the spectrophotometric Trolox-equivalent antioxidant capacity (TEAC) method. From a sample of pregnant women (n = 319, average age 30.84 ± 5.09 years) in 80, the levels of cotinine and oxidative stress markers were analyzed. Results: Among the 80 pregnant women, 5% (7.4% confirmed by cotinine) reported being current smokers and 25% reported passive smoking in the household (18.8% confirmed by cotinine). The Kappa was 0.78 for smokers and 0.22 for ETS-exposed nonsmokers. Pregnant women in the ETS-exposed group had significantly reduced AC compared to both the nonsmoker (ETS−) and the smoker groups (p < 0.05). Nonsmokers had significantly lower levels of 8-isoprostane than smokers (p < 0.01) and ETS-exposed nonsmokers (p < 0.05). Correlations between urine levels of cotinine and AC were positive in ETS-exposed nonsmokers. Conclusion: A harmful association of active and passive smoking and oxidative stress parameters among pregnant women has been indicated. View Full-Text
Keywords: environmental tobacco smoke (ETS); pregnant women; questionnaire; urinary cotinine; oxidative stress parameters environmental tobacco smoke (ETS); pregnant women; questionnaire; urinary cotinine; oxidative stress parameters
MDPI and ACS Style

Argalasova, L.; Zitnanova, I.; Vondrova, D.; Dvorakova, M.; Laubertova, L.; Jurkovicova, J.; Stofko, J.; Weitzman, M.; Waczulikova, I.; Simko, M. Self-Reported Exposure to ETS (Environmental Tobacco Smoke), Urinary Cotinine, and Oxidative Stress Parameters in Pregnant Women—The Pilot Study. Int. J. Environ. Res. Public Health 2019, 16, 1656.

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