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Fetal Cerebral Artery Mitochondrion as Target of Prenatal Alcohol Exposure

Department Pharmacology, College of Medicine, The University of Tennessee Health Science Center, Memphis, TN 38163, USA
Int. J. Environ. Res. Public Health 2019, 16(9), 1586; https://doi.org/10.3390/ijerph16091586
Received: 10 April 2019 / Revised: 29 April 2019 / Accepted: 3 May 2019 / Published: 7 May 2019
(This article belongs to the Special Issue Fetal Alcohol Spectrum Disorder (FASD))
Prenatal alcohol exposure results in an array of developmental abnormalities known as fetal alcohol spectrum disorders (FASDs). Despite the high prevalence of FASDs, therapeutic interventions against accidental or intended exposure of developing fetuses to alcohol are limited. This review outlines current knowledge about mitochondria in cerebral blood vessels as a potential target for anti-FASDs intervention. First, it describes the multifaceted role of mitochondria in maintaining the cerebral artery diameter as shown in adult tissue. Second, current literature on alcohol-driven damage of mitochondrial morphology and function in several fetal tissues, including liver, heart, and brain is summarized. The functional consequences of alcohol exposure in these organs include morphological enlargement of mitochondria, increased oxidative stress, and alteration of cellular respiration. These studies point to a tissue-specific effect of alcohol on mitochondrial function and a particular vulnerability of fetal mitochondria to alcohol exposure when compared to adult counterparts. Third, recent work from our group describing persistent changes in fetal baboon cerebral artery proteome following three episodes of prenatal alcohol exposure is reviewed. In conclusion, the consequences of prenatal alcohol exposure on cerebral artery mitochondria constitute an open field of investigation and, eventually, a point of therapeutic intervention against FASDs. View Full-Text
Keywords: maternal drinking; intrauterine alcohol; alcohol in utero; nonhuman primate; basilar artery; neurovascular unit maternal drinking; intrauterine alcohol; alcohol in utero; nonhuman primate; basilar artery; neurovascular unit
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Bukiya, A.N. Fetal Cerebral Artery Mitochondrion as Target of Prenatal Alcohol Exposure. Int. J. Environ. Res. Public Health 2019, 16, 1586.

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