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Open AccessCase Report

Intracellular Aluminium in Inflammatory and Glial Cells in Cerebral Amyloid Angiopathy: A Case Report

1
The Birchall Centre, Lennard-Jones Laboratories, Keele University, Staffordshire ST5 5BG, UK
2
School of Medicine, David Weatherly Building, Keele University, Staffordshire ST5 5BG, UK
3
Department of Clinical Neuropathology, Kings College Hospital, London SE5 9RS, UK
*
Author to whom correspondence should be addressed.
Int. J. Environ. Res. Public Health 2019, 16(8), 1459; https://doi.org/10.3390/ijerph16081459
Received: 19 March 2019 / Revised: 16 April 2019 / Accepted: 18 April 2019 / Published: 24 April 2019
(1) Introduction: In 2006, we reported on very high levels of aluminium in brain tissue in an unusual case of cerebral amyloid angiopathy (CAA). The individual concerned had been exposed to extremely high levels of aluminium in their potable water due to a notorious pollution incident in Camelford, Cornwall, in the United Kingdom. The recent development of aluminium-specific fluorescence microscopy has now allowed for the location of aluminium in this brain to be identified. (2) Case Summary: We used aluminium-specific fluorescence microscopy in parallel with Congo red staining and polarised light to identify the location of aluminium and amyloid in brain tissue from an individual who had died from a rare and unusual case of CAA. Aluminium was almost exclusively intracellular and predominantly in inflammatory and glial cells including microglia, astrocytes, lymphocytes and cells lining the choroid plexus. Complementary staining with Congo red demonstrated that aluminium and amyloid were not co-located in these tissues. (3) Discussion: The observation of predominantly intracellular aluminium in these tissues was novel and something similar has only previously been observed in cases of autism. The results suggest a strong inflammatory component in this case and support a role for aluminium in this rare and unusual case of CAA. View Full-Text
Keywords: cerebral amyloid angiopathy; brain aluminium; pro-inflammatory cells; human exposure to aluminium; Camelford in Cornwall cerebral amyloid angiopathy; brain aluminium; pro-inflammatory cells; human exposure to aluminium; Camelford in Cornwall
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Mold, M.; Cottle, J.; King, A.; Exley, C. Intracellular Aluminium in Inflammatory and Glial Cells in Cerebral Amyloid Angiopathy: A Case Report. Int. J. Environ. Res. Public Health 2019, 16, 1459.

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