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Open AccessArticle

Early Lifestyle Interventions in People with Impaired Glucose Tolerance in Northern Colombia: The DEMOJUAN Project

1
Department of Medical and Population Health Research, Herbert Wertheim College of Medicine, Florida International University, Miami, FL 33178, USA
2
Department of Public Health, Faculty of Medicine, University of Helsinki, 00100 Helsinki, Finland
3
Department of Public Health, Universidad del Norte, Barranquilla 080001, Colombia
4
Centro de Investigation Sanitaria, Barranquilla 080001, Colombia
5
Faculty of Medicine, Riga Stradins University, LV-1007 Riga, Latvia
6
Departamento de Matemáticas y Estadística, Universidad del Norte, Barranquilla 080001, Colombia
7
Department of Public Health Solutions, National Institute for Health and Welfare, 00271 Helsinki, Finland
8
Saudi Diabetes Research Group, King Abdulaziz University, Jeddah 21589, Saudi Arabia
*
Author to whom correspondence should be addressed.
Int. J. Environ. Res. Public Health 2019, 16(8), 1403; https://doi.org/10.3390/ijerph16081403
Received: 22 February 2019 / Revised: 12 April 2019 / Accepted: 15 April 2019 / Published: 18 April 2019
(This article belongs to the Special Issue Implementation Research in Chronic Disease Prevention and Control)
Background: The objective of the demonstration project for type 2 diabetes prevention in the Barranquilla and Juan Mina (DEMOJUAN) study was to investigate the extent to which it is possible to reach normal glucose metabolism with early lifestyle interventions in people at high risk of type 2 diabetes (prediabetes), compared with those who receive standard usual care. Methods: DEMOJUAN was a randomized controlled trial conducted in Juan Mina and Barranquilla, Northern Colombia. Eligible participants were randomized into one of three groups (control group, initial nutritional intervention, and initial physical activity intervention). The duration of the intervention was 24 months. The main study outcome in the present analysis was reversion to normoglycemia. Relative risks and their corresponding 95% confidence intervals were calculated for reversal to normoglycemia and T2D incidence. Results: There was no statistically significant association between the intervention groups and reversion to normoglycemia. The relative risk of reversion to normoglycemia was 0.88 (95% CI 0.70–1.12) for the initial nutritional intervention group participants and 0.95 (95% CI 0.75–1.20) for the initial physical activity intervention group participants. Conclusions: Our study did not find any statistically significant differences in reversion to normoglycemia or the development of type 2 diabetes between the intervention groups and the control group in this population. View Full-Text
Keywords: glucose metabolism disorders; primary prevention; South America; population; field trial glucose metabolism disorders; primary prevention; South America; population; field trial
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MDPI and ACS Style

Barengo, N.C.; Acosta, T.; Arrieta, A.; Ricaurte, C.; Smits, D.; Florez, K.; Tuomilehto, J.O. Early Lifestyle Interventions in People with Impaired Glucose Tolerance in Northern Colombia: The DEMOJUAN Project. Int. J. Environ. Res. Public Health 2019, 16, 1403.

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