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Open AccessArticle

Lack of Association between Cytokine Genetic Polymorphisms in Takayasu’s Arteritis in Mexican Patients

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Immunology Department, Instituto Nacional de Cardiología “Ignacio Chávez”. Juan Badiano No. 1, Col. Sección XVI, Tlalpan, México City 14080, Mexico
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Physiology Department, Instituto Nacional de Cardiología “Ignacio Chávez”, Juan Badiano No. 1, Col. Sección XVI, Tlalpan, Mexico City 14080, Mexico
*
Author to whom correspondence should be addressed.
Int. J. Environ. Res. Public Health 2019, 16(23), 4863; https://doi.org/10.3390/ijerph16234863
Received: 11 October 2019 / Revised: 25 November 2019 / Accepted: 27 November 2019 / Published: 3 December 2019
Aim: To investigate the relation between polymorphisms in the interleukin 10 (IL)-10, tumor necrosis factor (TNF)-α, transforming growth factor (TGF)-β and interferon (IFN)-γ genes and Takayasu’s arteritis in the Mexican population. Methods: A case-control study was performed to investigate the associations of IL-10, TNF-α, TGF-β and IFN-γ polymorphisms in a sample of 52 Takayasu’s arteritis patients, diagnosed according to the criteria of the American College of Rheumatology and EULAR PRINTO criteria when the patients were under 18 years of age; 60 clinically healthy unrelated Mexican individuals by the 5′ exonuclease TaqMan polymerase chain reaction. Polymorphic haplotypes were constructed after linkage disequilibrium analysis. Results: Significant differences were not found in the distribution for genotype and allele frequencies of the polymorphisms studied between healthy controls and Takayasu´s arteritis patients. Likewise, significant associations were not detected in the haplotype analysis with the different genes studied. Conclusions: These findings suggest that the polymorphisms in IL-10, TNF-α, TGF-β and IFN-γ might not contribute to the susceptibility of Takayasu´s arteritis in the Mexican population. View Full-Text
Keywords: cytokines; Takayasu′s arteritis; polymorphisms; Mexican population cytokines; Takayasu′s arteritis; polymorphisms; Mexican population
MDPI and ACS Style

Soto, M.E.; Huesca-Gómez, C.; Torres-Paz, Y.; Fuentevilla-Álvarez, G.; Gamboa, R. Lack of Association between Cytokine Genetic Polymorphisms in Takayasu’s Arteritis in Mexican Patients. Int. J. Environ. Res. Public Health 2019, 16, 4863.

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