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Open AccessReview

Genomics of Particulate Matter Exposure Associated Cardiopulmonary Disease: A Narrative Review

1
Department of Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, NYU, School of Medicine, New York, NY 10016, USA
2
Department of Environmental Medicine, New York University, School of Medicine, New York, NY 10016, USA
3
Bureau of Health Services, Fire Department of New York, Brooklyn, NY 11201, USA
*
Author to whom correspondence should be addressed.
Int. J. Environ. Res. Public Health 2019, 16(22), 4335; https://doi.org/10.3390/ijerph16224335
Received: 23 September 2019 / Revised: 28 October 2019 / Accepted: 30 October 2019 / Published: 7 November 2019
(This article belongs to the Special Issue Air Pollution: Occupational Exposure and Public Health)
Particulate matter (PM) exposure is associated with the development of cardiopulmonary disease. Our group has studied the adverse health effects of World Trade Center particulate matter (WTC-PM) exposure on firefighters. To fully understand the complex interplay between exposure, organism, and resultant disease phenotype, it is vital to analyze the underlying role of genomics in mediating this relationship. A PubMed search was performed focused on environmental exposure, genomics, and cardiopulmonary disease. We included original research published within 10 years, on epigenetic modifications and specific genetic or allelic variants. The initial search resulted in 95 studies. We excluded manuscripts that focused on work-related chemicals, heavy metals and tobacco smoke as primary sources of exposure, as well as reviews, prenatal research, and secondary research studies. Seven full-text articles met pre-determined inclusion criteria, and were reviewed. The effects of air pollution were evaluated in terms of methylation (n = 3), oxidative stress (n = 2), and genetic variants (n = 2). There is evidence to suggest that genomics plays a meditating role in the formation of adverse cardiopulmonary symptoms and diseases that surface after exposure events. Genomic modifications and variations affect the association between environmental exposure and cardiopulmonary disease, but additional research is needed to further define this relationship. View Full-Text
Keywords: genomics; epigenetics; particulate matter; cardiopulmonary disease genomics; epigenetics; particulate matter; cardiopulmonary disease
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Citron, J.; Willcocks, E.; Crowley, G.; Kwon, S.; Nolan, A. Genomics of Particulate Matter Exposure Associated Cardiopulmonary Disease: A Narrative Review. Int. J. Environ. Res. Public Health 2019, 16, 4335.

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