Work-Related Stress, Physio-Pathological Mechanisms, and the Influence of Environmental Genetic Factors

Cannizzaro, Emanuele; Ramaci, Tiziana; Cirrincione, Luigi; Plescia, Fulvio

doi:10.3390/ijerph16204031

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Work-Related Stress, Physio-Pathological Mechanisms, and the Influence of Environmental Genetic Factors

¹

Department of Health Promotion Sciences Maternal and Infantile Care, Internal Medicine and Medical Specialities “Giuseppe D’Alessandro”, University of Palermo, via del Vespro 133, 90127 Palermo, Italy

²

Faculty of Human and Social Sciences, Kore University of Enna, 94100 Enna, Italy

^*

Author to whom correspondence should be addressed.

Int. J. Environ. Res. Public Health 2019, 16(20), 4031; https://doi.org/10.3390/ijerph16204031

Submission received: 27 September 2019 / Revised: 18 October 2019 / Accepted: 19 October 2019 / Published: 21 October 2019

(This article belongs to the Special Issue Stress and Work)

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Abstract

Work-related stress is a growing health problem in modern society. The stress response is characterized by numerous neurochemicals, neuroendocrine and immune modifications that involve various neurological systems and circuits, and regulation of the gene expression of the different receptors. In this regard, a lot of research has focused the attention on the role played by the environment in influencing gene expression, which in turn can control the stress response. In particular, genetic factors can moderate the sensitivities of specific types of neural cells or circuits mediating the imprinting of the environment on different biological systems. In this current review, we wish to analyze systematic reviews and recent experimental research on the physio-pathological mechanisms that underline stress-related responses. In particular, we analyze the relationship between genetic and epigenetic factors in the stress response.

Keywords: work-related stress; environment; genetic factors; stress

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MDPI and ACS Style

Cannizzaro, E.; Ramaci, T.; Cirrincione, L.; Plescia, F. Work-Related Stress, Physio-Pathological Mechanisms, and the Influence of Environmental Genetic Factors. Int. J. Environ. Res. Public Health 2019, 16, 4031. https://doi.org/10.3390/ijerph16204031

AMA Style

Cannizzaro E, Ramaci T, Cirrincione L, Plescia F. Work-Related Stress, Physio-Pathological Mechanisms, and the Influence of Environmental Genetic Factors. International Journal of Environmental Research and Public Health. 2019; 16(20):4031. https://doi.org/10.3390/ijerph16204031

Chicago/Turabian Style

Cannizzaro, Emanuele, Tiziana Ramaci, Luigi Cirrincione, and Fulvio Plescia. 2019. "Work-Related Stress, Physio-Pathological Mechanisms, and the Influence of Environmental Genetic Factors" International Journal of Environmental Research and Public Health 16, no. 20: 4031. https://doi.org/10.3390/ijerph16204031

APA Style

Cannizzaro, E., Ramaci, T., Cirrincione, L., & Plescia, F. (2019). Work-Related Stress, Physio-Pathological Mechanisms, and the Influence of Environmental Genetic Factors. International Journal of Environmental Research and Public Health, 16(20), 4031. https://doi.org/10.3390/ijerph16204031

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

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Work-Related Stress, Physio-Pathological Mechanisms, and the Influence of Environmental Genetic Factors

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