Rapid urbanization and industrialization in developing countries have caused an increase in air pollutant concentrations, and this has attracted public concern due to the resulting harmful effects to health. Here we present, through the spatial-temporal characteristics of six criteria air pollutants (PM
2.5, PM
10, SO
2, NO
2, CO, and O
3) in Sichuan, a human health risk assessment framework conducted to evaluate the health risk of different age groups caused by ambient air pollutants. Public health resilience was evaluated with respect to the risk resulting from ambient air pollutants, and a spatial inequality analysis between the risk caused by ambient air pollutants and hospital density in Sichuan was performed based on the Lorenz curve and Gini coefficient. The results indicated that high concentrations of PM
2.5 (47.7 μg m
−3) and PM
10 (75.9 μg m
−3) were observed in the Sichuan Basin; these two air pollutants posed a high risk to infants. The high risk caused by PM
2.5 was mainly distributed in Sichuan Basin (1.14) and that caused by PM
10 was principally distributed in Zigong (1.01). Additionally, the infants in Aba and Ganzi had high health resilience to the risk caused by PM
2.5 (3.89 and 4.79, respectively) and PM
10 (3.28 and 2.77, respectively), which was explained by the low risk in these two regions. These regions and Sichuan had severe spatial inequality between the infant hazard quotient caused by PM
2.5 (
G = 0.518,
G = 0.493, and
G = 0.456, respectively) and hospital density. This spatial inequality was also caused by PM
10 (
G = 0.525,
G = 0.526, and
G = 0.466, respectively), which is mainly attributed to the imbalance between hospital distribution and risk caused by PM
2.5 (PM
10) in these two areas. Such research could provide a basis for the formulation of medical construction and future air pollution control measures in Sichuan.
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