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Open AccessFeature PaperArticle

Micronuclei in Exfoliated Buccal Cells of Children Living in a Cluster Area of Salento (Southern Italy) with a High Incidence of Lung Cancer: The IMP.AIR Study

1
Department of Biological and Environmental Science and Technology, University of Salento, via Monteroni 165, 73100 Lecce, Italy
2
Interuniversity Research Centre on Influenza and other Tnsmitted Infections (CIRI-IT), 16132 Genoa, Italy
3
Local Health Authority ASL LE, 73100 Lecce, Italy
4
Euro Mediterranean Scientific Biomedical Institute, 72100 Brindisi, Italy
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Int. J. Environ. Res. Public Health 2018, 15(8), 1659; https://doi.org/10.3390/ijerph15081659
Received: 25 June 2018 / Revised: 31 July 2018 / Accepted: 1 August 2018 / Published: 5 August 2018
(This article belongs to the Special Issue Environmental Carcinogens)
During the years 2014–2016 the University of Salento performed the “Impact of Air Quality on Health of Residents in the Municipalities of Cutrofiano, Galatina, Sogliano Cavour, Soleto and Sternatia” (IMP.AIR) study, an epidemiological-molecular research project aiming to evaluate early DNA damage in children living in an area of Salento with high incidence of lung cancer among the male population. One hundred and twenty-two children aged 6–8 years attending primary school were enrolled and the frequency of micronucleated cells (MNC) in oral mucosa was evaluated. In addition, a questionnaire was administered to parents to obtain information about personal data, anthropometric characteristics and lifestyles (physical activity, food habits, family context) of the children and perform a multivariate analysis to detect any factors associated with MNC occurrence. Data on airborne pollutants detected in the study area were acquired by the Regional Agency for the Environmental Protection. The presence of MNC was highlighted in about 42% of children with a mean MNC frequency of 0.49‰. The frequency of MNC was associated to obesity, consumption of red or processed meat and having a mother who smokes. Moreover, the prevalence of biomarkers was higher than in another area of Salento not included in the cluster area. View Full-Text
Keywords: micronucleus; exfoliated buccal cells; children; Salento; IMP.AIR study micronucleus; exfoliated buccal cells; children; Salento; IMP.AIR study
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Idolo, A.; Grassi, T.; Bagordo, F.; Panico, A.; De Giorgi, M.; Serio, F.; Guido, M.; Piscitelli, P.; De Filippis, G.; Raho, A.; De Donno, A. Micronuclei in Exfoliated Buccal Cells of Children Living in a Cluster Area of Salento (Southern Italy) with a High Incidence of Lung Cancer: The IMP.AIR Study. Int. J. Environ. Res. Public Health 2018, 15, 1659.

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