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Open AccessArticle

Gender Differences in the Association between Serum Uric Acid and Prediabetes: A Six-Year Longitudinal Cohort Study

1
School of Public Health, Capital Medical University, Beijing 100069, China
2
Beijing Municipal Key Laboratory of Clinical Epidemiology, Capital Medical University, Beijing 100069, China
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State Key Lab of Transducer Technology, Institute of Electronics, Chinese Academy of Sciences, Beijing 100049, China
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Institute of Electronics, University of Chinese Academy of Sciences, Beijing 101408, China
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Computer Department, Beijing Information Science and Technology University, Beijing 100101, China
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Beijing National Laboratory for Molecular Sciences, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China
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Department of Information, Beijing Physical Examination Center, Beijing 100077, China
*
Authors to whom correspondence should be addressed.
Int. J. Environ. Res. Public Health 2018, 15(7), 1560; https://doi.org/10.3390/ijerph15071560
Received: 1 July 2018 / Revised: 17 July 2018 / Accepted: 17 July 2018 / Published: 23 July 2018
(This article belongs to the Section Health Behavior, Chronic Disease and Health Promotion)
This study aimed to examine gender differences in the association between serum uric acid (SUA) and the risk of prediabetes in a longitudinal cohort. A total of 8237 participants in the Beijing Health Management Cohort study were recruited and surveyed during 2008–2009, and followed up in 2011–2012 and 2014–2015 surveys. Generalized estimating equation (GEE) models were used to evaluate the association between SUA and prediabetes. Furthermore, subgroup analyses assessed the primary outcome according to status of abdominal obesity, age and status of hypertension. During six years of follow-up, we identified 1083 prediabetes events. The GEE analyses confirmed and clarified the association between SUA and prediabetes (RR = 1.362; 95% CI = 1.095–1.696; p = 0.006) after adjusting for other potential confounders, especially in females (RR = 2.109; 95% CI = 1.329–3.347; p = 0.002). In addition, this association was stronger in the subgroup of females aged ≥48 years old (RR = 2.384; 95% CI = 1.417–4.010; p = 0.001). The risk for prediabetes increased significantly with increasing SUA for females in the Chinese population. This association was strongly confirmed in older females aged ≥48 years old rather than in younger females, which may provide clues for pathogenic mechanisms of gender differences in the association between SUA and prediabetes. View Full-Text
Keywords: serum uric acid; prediabetes; generalized estimating equation; longitudinal cohort study serum uric acid; prediabetes; generalized estimating equation; longitudinal cohort study
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Liu, J.; Zhao, Z.; Mu, Y.; Zou, X.; Zou, D.; Zhang, J.; Chen, S.; Tao, L.; Guo, X. Gender Differences in the Association between Serum Uric Acid and Prediabetes: A Six-Year Longitudinal Cohort Study. Int. J. Environ. Res. Public Health 2018, 15, 1560.

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