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Vascular Hyperactivity in the Rat Renal Aorta Participates in the Association between Immune Complex-Mediated Glomerulonephritis and Systemic Hypertension

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Departamento de Patología, Instituto Nacional de Cardiología “Ignacio Chávez”, Ciudad de México 14080, México
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Departamento de Fisiología Instituto Nacional de Cardiología “Ignacio Chávez”, Ciudad de México 14080, México
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Departamento de Biología Celular y Tisular, Facultad de Medicina, Universidad Nacional Autónoma de México, Ciudad de México 04510, México
*
Author to whom correspondence should be addressed.
Israel Pérez-Torres and Bernardo Moguel-González share the first authorship of this paper.
Int. J. Environ. Res. Public Health 2018, 15(6), 1164; https://doi.org/10.3390/ijerph15061164
Received: 21 April 2018 / Revised: 24 May 2018 / Accepted: 30 May 2018 / Published: 3 June 2018
Introduction: systemic hypertension (SH) involving endothelial dysfunction contributes to immune complex-mediated glomerulonephritis (ICGN). Objective, we demonstrate a relationship between ICGN and SH by analyzing vascular reactivity in renal aortic rings. Methods: 48 male Wistar rats were divided into four groups: (a) control (C); (b) injected with bovine serum albumin (BSA); (c) receiving 200 mg/L NAME (an analog of arginine that inhibits NO production) in drinking water; and (d) receiving BSA and 200 mg/L NAME. Rats were pre-immunized subcutaneously with BSA and Freund’s adjuvant. After 10 days, groups (b) and (c) received 1 mg/mL of BSA in saline intravenous (IV) daily for 35 days. The urine of 24 h was measured at days 0, 15, 30 and 45. Results: vascular reactivity to norepinephrine (NE), acetylcholine (Ach) and NAME were tested. Creatinine clearance, vasodilatation, eNOS and elastic fibers were diminished (p ≤ 0.001). Blood pressure, vasoconstriction, iNOS were increased, and glomerular alterations were observed in groups (b), (c) and (d) when compared to group (a) (p ≤ 0.001). Conclusions: SH contributes to the development of progressive renal disease in ICGN. Alterations of the vascular reactivity are mediated by the endothelium in the renal aorta. Thus, the endothelium plays a determinant role in the production of vasoactive substances such as NO during this process. View Full-Text
Keywords: glomerulonephritis; hypertension; reactivity vascular; eNOS; iNOS; immune complex glomerulonephritis; hypertension; reactivity vascular; eNOS; iNOS; immune complex
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Pérez-Torres, I.; Moguel-González, B.; Soria-Castro, E.; Guarner-Lans, V.; Avila-Casado, M.D.C.; Goes, T.I.F.V. Vascular Hyperactivity in the Rat Renal Aorta Participates in the Association between Immune Complex-Mediated Glomerulonephritis and Systemic Hypertension. Int. J. Environ. Res. Public Health 2018, 15, 1164.

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