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Open AccessArticle

Factors Contributing to the Duration of Chemotherapy-Induced Severe Oral Mucositis in Oncopediatric Patients

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Departament of Statistics, Universidade Federal da Paraíba, João Pessoa, Paraíba 5045, Brazil
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Departament of Clinical and Social Dentistry, Universidade Federal da Paraíba, João Pessoa, Paraíba 50445, Brazil
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Author to whom correspondence should be addressed.
Rua: Inácio Ramos de Andrade, 398, apt. 301, Ed. Filipéia, Jardim Cidade Universitária/CEP: 58052-210, João Pessoa (PB), Brazil.
Int. J. Environ. Res. Public Health 2018, 15(6), 1153; https://doi.org/10.3390/ijerph15061153
Received: 7 March 2018 / Revised: 25 May 2018 / Accepted: 27 May 2018 / Published: 1 June 2018
This study analyzes the factors contributing to the duration of severe oral mucositis in oncopediatric patients. A longitudinal study was conducted in the pediatric department of a cancer referral hospital between 2013 and 2017. Seventy-three patients diagnosed with cancer undergoing chemotherapy protocols were analyzed. Oral evaluations were performed using the Modified Oral Assessment Guide criteria, and the data were collected from the patients’ records. The Kaplan-Meier method was used to estimate survival curves. Most patients were males (52.1%), of mixed race (“pardo”) (49.3%), with a mean age of 7.56 years (±5.34). There was a predominance of patients diagnosed with solid tumors (52.1%), with no metastasis (86.3%), using natural product chemotherapeutics (56.2%), who had not undergone a bone marrow transplant (97.3%); amputation was observed in 35.6% of patients, while death rates were as high as 8.2%. The survival analysis estimated a mean time of 30.6 days until complete remission of severe oral mucositis. The regression analysis showed that patients over 10 years old had a median mucositis duration 1.4 times greater than those at the age of 10 years or younger. Patients without metastasis had a median mucositis duration 1.7 times greater than those with metastasis (p-value ≤ 0.10). Increasing age and the absence of metastasis were conditions that prolonged the duration of severe oral mucositis. View Full-Text
Keywords: mucositis; child; cancer mucositis; child; cancer
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Damascena, L.C.L.; De Lucena, N.N.N.; Ribeiro, I.L.A.; De Araujo, T.L.P.; De Castro, R.D.; Bonan, P.R.F.; Lima Neto, E.D.A.; De Araújo Filho, L.M.; Valença, A.M.G. Factors Contributing to the Duration of Chemotherapy-Induced Severe Oral Mucositis in Oncopediatric Patients. Int. J. Environ. Res. Public Health 2018, 15, 1153.

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