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Open AccessArticle

Women’s Mid-Life Night Sweats and 2-Year Bone Mineral Density Changes: A Prospective, Observational Population-Based Investigation from the Canadian Multicentre Osteoporosis Study (CaMos)

by Evelyn M. M. Wong 1,2,3,4,5, George Tomlinson 4,5,6, Marsha M. Pinto 3,7, Claudie Berger 8, Angela M. Cheung 2,3,4,5,6,7,9 and Jerilynn C. Prior 1,10,11,12,*
1
Division of Endocrinology and Metabolism, Department of Medicine, University of British Columbia, Vancouver, BC V5Z 1M9, Canada
2
Division of Endocrinology and Metabolism, Department of Medicine, University Health Network and Sinai Health System, University of Toronto, Toronto, ON M5G 2C4, Canada
3
Osteoporosis Program, University Health Network, Toronto, ON M5G 2C4, Canada
4
Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, ON M5G 2C4, Canada
5
Toronto General Hospital Research Institute, Toronto, ON M5G 2C4, Canada
6
Division of General Internal Medicine, Department of Medicine, University Health Network and Sinai Health System, University of Toronto, Toronto, ON M5G 2C4, Canada
7
Institute of Medical Sciences, University of Toronto, Toronto, ON M5G 2C4, Canada
8
Canadian Multicentre Osteoporosis Study Data Management Group, McGill University, Montreal, ON H4A 3S5, Canada
9
Centre of Excellence in Skeletal Health Assessment, University of Toronto, Toronto, ON M5G 2C4, Canada
10
Centre for Menstrual Cycle and Ovulation Research, University of British Columbia, Vancouver, BC V5Z 1M9, Canada
11
School of Population and Public Health, University of British Columbia, Vancouver, BC V6T 1Z3, Canada
12
BC Women’s Health Research Institute, Vancouver, BC V6H 2N9, Canada
*
Author to whom correspondence should be addressed.
Int. J. Environ. Res. Public Health 2018, 15(6), 1079; https://doi.org/10.3390/ijerph15061079
Received: 14 March 2018 / Revised: 14 May 2018 / Accepted: 19 May 2018 / Published: 26 May 2018
(This article belongs to the Special Issue New Concepts in Women’s Bone Health)
Women’s hot flushes and night sweats, collectively called vasomotor symptoms (VMS), are maximal (79%) in late perimenopause. The evidence describing whether VMS are associated with loss of areal bone mineral density (BMD) is mixed. We examined baseline and 2-year data for 1570 randomly selected women aged 43–63 in the Canadian Multicentre Osteoporosis Study (CaMos), a prospective Canada-wide study; we used linear regression to assess the relationship of night sweats (VMSn) with BMD and its changes. Clinically important VMSn occurred for 12.2%. Women with VMSn were slightly younger (54.5 vs. 55.3 years, p = 0.02) and less likely to use sex steroid therapies (39.8% vs. 51.4%, p < 0.05). BMD at the lumbar spine (L1-4), femoral neck (FN) and total hip (TH) were similar between those with/without VMSn. In adjusted models, we did not find a significant association between VMSn and 2-year change in L1-4, FN and TH BMD. Age, reproductive status, weight, sex steroid therapy and smoking status were associated with 2-year change in BMD. Incident fractures over 2 years also did not differ by VMSn. Our analyses were restricted to VMSn and may not truly capture the relationship between VMS and BMD. Additional research involving VMS, bone loss and fracture incidence is needed. View Full-Text
Keywords: vasomotor symptoms; hot flashes; night sweats; menopause; women; perimenopause; osteoporosis; spinal fractures; hip fractures; bone density vasomotor symptoms; hot flashes; night sweats; menopause; women; perimenopause; osteoporosis; spinal fractures; hip fractures; bone density
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Wong, E.M.M.; Tomlinson, G.; Pinto, M.M.; Berger, C.; Cheung, A.M.; Prior, J.C. Women’s Mid-Life Night Sweats and 2-Year Bone Mineral Density Changes: A Prospective, Observational Population-Based Investigation from the Canadian Multicentre Osteoporosis Study (CaMos). Int. J. Environ. Res. Public Health 2018, 15, 1079.

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