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BMI and BMD: The Potential Interplay between Obesity and Bone Fragility

Department of Endocrinology and Diabetes, University Campus Bio-Medico, Via Alvaro del Portillo, 21, Rome 00128, Italy
Department of Experimental Medicine, Sapienza University of Rome, Rome 00185, Italy
Department of Experimental Medicine, Polo Pontino, Sapienza University of Rome, Rome 00185, Italy
Centre of Diabetes, Barts & the London School of Medicine, London E1 2AT, UK
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editors: Marlena Kruger and Hope Weiler
Int. J. Environ. Res. Public Health 2016, 13(6), 544;
Received: 27 March 2016 / Revised: 12 May 2016 / Accepted: 19 May 2016 / Published: 28 May 2016
(This article belongs to the Special Issue Bone Health: Nutritional Perspectives)
PDF [777 KB, uploaded 28 May 2016]


Recent evidence demonstrating an increased fracture risk among obese individuals suggests that adipose tissue may negatively impact bone health, challenging the traditional paradigm of fat mass playing a protective role towards bone health. White adipose tissue, far from being a mere energy depot, is a dynamic tissue actively implicated in metabolic reactions, and in fact secretes several hormones called adipokines and inflammatory factors that may in turn promote bone resorption. More specifically, Visceral Adipose Tissue (VAT) may potentially prove detrimental. It is widely acknowledged that obesity is positively associated to many chronic disorders such as metabolic syndrome, dyslipidemia and type 2 diabetes, conditions that could themselves affect bone health. Although aging is largely known to decrease bone strength, little is yet known on the mechanisms via which obesity and its comorbidities may contribute to such damage. Given the exponentially growing obesity rate in recent years and the increased life expectancy of western countries it appears of utmost importance to timely focus on this topic. View Full-Text
Keywords: osteoporosis; obesity; inflammation; fracture; body composition osteoporosis; obesity; inflammation; fracture; body composition

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Palermo, A.; Tuccinardi, D.; Defeudis, G.; Watanabe, M.; D’Onofrio, L.; Lauria Pantano, A.; Napoli, N.; Pozzilli, P.; Manfrini, S. BMI and BMD: The Potential Interplay between Obesity and Bone Fragility. Int. J. Environ. Res. Public Health 2016, 13, 544.

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