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Int. J. Environ. Res. Public Health 2016, 13(6), 525;

Preconceptional Iron Intake and Gestational Diabetes Mellitus

Department of Epidemiology, Boston University School of Public Health, Boston, MA 02118, USA
Slone Epidemiology Center at Boston University, Boston, MA 02215, USA
Author to whom correspondence should be addressed.
Academic Editor: Omorogieva Ojo
Received: 15 March 2016 / Revised: 9 May 2016 / Accepted: 16 May 2016 / Published: 24 May 2016
(This article belongs to the Collection Health Care and Diabetes)
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Our objective was to assess the impact of preconceptional heme and non-heme iron on gestational diabetes mellitius (GDM) in the Boston University Slone Epidemiology Birth Defects Study (BDS). This retrospective cohort analysis included 7229 participants enrolled in the BDS between 1998 and 2008 who gave birth to non-malformed infants and were free of pre-existing diabetes. All data were collected through structured interviews conducted within 6 months of delivery. Calorie-adjusted and multivariable odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using logistic regression models. Preconceptional dietary heme iron was modestly associated with an elevated risk of GDM among those (multivariable OR comparing the fifth quintile to the first: 1.55; 95% CI 0.98, 2.46). Conversely, preconceptional dietary non-heme iron was associated with a decreased risk of GDM among those in the fifth quintile of intake compared to the first (multivariable OR: 0.48; 95% CI 0.28, 0.81). Women who consumed supplemental iron during preconception also had a decreased risk of GDM (multivariable OR: 0.78; 95% CI 0.60, 1.02). In conclusion, our data support a positive association between preconceptional heme iron intake and GDM and an inverse association between preconceptional non-heme iron intake from foods and preconceptional intake from supplements. View Full-Text
Keywords: iron; gestational diabetes; diet; pregnancy iron; gestational diabetes; diet; pregnancy
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Darling, A.M.; Mitchell, A.A.; Werler, M.M. Preconceptional Iron Intake and Gestational Diabetes Mellitus. Int. J. Environ. Res. Public Health 2016, 13, 525.

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