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Int. J. Environ. Res. Public Health 2016, 13(10), 989;

Influence of Bisphenol A on Type 2 Diabetes Mellitus

COLEMAN S.r.l., Naples 80100, Italy
Dipartimento di Medicina Clinica e Chirurgia, Università di Napoli “Federico II”, Naples 80130, Italy
These authors contributed equally to this work.
Author to whom correspondence should be addressed.
Received: 8 July 2016 / Accepted: 28 September 2016 / Published: 6 October 2016
(This article belongs to the Special Issue Environmental Diseases)
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Bisphenol A (BPA) is an organic synthetic compound employed to produce plastics and epoxy resins. It is used as a structural component in polycarbonate beverage bottles and as coating for metal surface in food containers and packaging. The adverse effects of BPA on human health are widely disputed. BPA has been recently associated with a wide variety of medical disorders and, in particular, it was identified as potential endocrine-disrupting compound with diabetogenic action. Most of the clinical observational studies in humans reveal a positive link between BPA exposure, evaluated by the measurement of urinary BPA levels, and the risk of developing type 2 diabetes mellitus. Clinical studies on humans and preclinical studies on in vivo, ex vivo, and in vitro models indicate that BPA, mostly at low doses, may have a role in increasing type 2 diabetes mellitus developmental risk, directly acting on pancreatic cells, in which BPA induces the impairment of insulin and glucagon secretion, triggers inhibition of cell growth and apoptosis, and acts on muscle, hepatic, and adipose cell function, triggering an insulin-resistant state. The current review summarizes the available evidences regarding the association between BPA and type 2 diabetes mellitus, focusing on both clinical and preclinical studies. View Full-Text
Keywords: bisphenol A; diabetes; insulin resistance bisphenol A; diabetes; insulin resistance
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Provvisiero, D.P.; Pivonello, C.; Muscogiuri, G.; Negri, M.; de Angelis, C.; Simeoli, C.; Pivonello, R.; Colao, A. Influence of Bisphenol A on Type 2 Diabetes Mellitus. Int. J. Environ. Res. Public Health 2016, 13, 989.

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