Next Article in Journal
Universal Stress Proteins as New Targets for Environmental and Therapeutic Interventions of Schistosomiasis
Next Article in Special Issue
Using Virtual Street Audits to Understand the Walkability of Older Adults’ Route Choices by Gender and Age
Previous Article in Journal
An Examination of the Ethnicity-Specific Prevalence of and Factors Associated with Substance Use and Misuse: Cross-Sectional Analysis of Croatian and Bosniak Adolescents in Bosnia and Herzegovina
Previous Article in Special Issue
Relationships of Community and Individual Level Social Capital with Activities of Daily Living and Death by Gender
Article Menu

Export Article

Open AccessArticle
Int. J. Environ. Res. Public Health 2016, 13(10), 969;

l-Arginine Enhances Resistance against Oxidative Stress and Heat Stress in Caenorhabditis elegans

Key laboratory for Molecular Enzymology and Engineering, The Ministry of Education, National Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University, Changchun 130012, China
Sports Science Research Institute of Jilin Province, Changchun 130022, China
The China-Japan Union Hospital of Jilin University, Changchun 130033, China
Authors to whom correspondence should be addressed.
Academic Editors: Matthew Lee Smith and Marcia G. Ory
Received: 4 May 2016 / Revised: 23 August 2016 / Accepted: 20 September 2016 / Published: 29 September 2016
(This article belongs to the Special Issue Aging and Health Promotion)
Full-Text   |   PDF [1500 KB, uploaded 29 September 2016]   |  


The antioxidant properties of l-arginine (l-Arg) in vivo, and its effect on enhancing resistance to oxidative stress and heat stress in Caenorhabditis elegans were investigated. C. elegans, a worm model popularly used in molecular and developmental biology, was used in the present study. Here, we report that l-Arg, at a concentration of 1 mM, prolonged C. elegans life by 26.98% and 37.02% under oxidative and heat stress, respectively. Further experiments indicated that the longevity-extending effects of l-Arg may be exerted by its free radical scavenging capacity and the upregulation of aging-associated gene expression in worms. This work is important in the context of numerous recent studies that concluded that environment stresses are associated with an increased population death rate. View Full-Text
Keywords: C. elegans; l-Arg; antiaging; antioxidant; free radical C. elegans; l-Arg; antiaging; antioxidant; free radical

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Supplementary material


Share & Cite This Article

MDPI and ACS Style

Ma, H.; Ma, Y.; Zhang, Z.; Zhao, Z.; Lin, R.; Zhu, J.; Guo, Y.; Xu, L. l-Arginine Enhances Resistance against Oxidative Stress and Heat Stress in Caenorhabditis elegans. Int. J. Environ. Res. Public Health 2016, 13, 969.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Int. J. Environ. Res. Public Health EISSN 1660-4601 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top