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Int. J. Environ. Res. Public Health 2015, 12(3), 3060-3076;

Correlation of Zinc with Oxidative Stress Biomarkers

Unit of Public Health, Hygiene and Environmental Health, Department of Preventive Medicine and Public Health, Food Science, Toxicology and Legal Medicine, University of Valencia, 46100 Valencia, Spain
CIBER Epidemiología y Salud Pública (CIBERESP), Instituto de Salud Carlos III, 28029 Madrid, Spain
Center for Advanced Research in Public Health (CSISP-FISABIO), 46010 Valencia, Spain
Genotyping and Genetic Diagnosis Unit Hospital Clinic Research Foundation and INCLIVA, University of Valencia, 46010 Valencia, Spain
Internal Medicine Department, Rio Hortega University Hospital, 47012 Valladolid, Spain
CIBER de Diabetes y Enfermedades Metabólicas Asociados (CIBERDEM), Instituto de Salud Carlos III, 28029 Madrid, Spain
These authors contributed equally to this work.
Author to whom correspondence should be addressed.
Academic Editor: Paul B. Tchounwou
Received: 21 January 2015 / Revised: 27 February 2015 / Accepted: 9 March 2015 / Published: 12 March 2015
(This article belongs to the Special Issue Preventive Medicine)
Full-Text   |   PDF [929 KB, uploaded 12 March 2015]   |  


Hypertension and smoking are related with oxidative stress (OS), which in turn reports on cellular aging. Zinc is an essential element involved in an individual’s physiology. The aim of this study was to evaluate the relation of zinc levels in serum and urine with OS and cellular aging and its effect on the development of hypertension. In a Spanish sample with 1500 individuals, subjects aged 20–59 years were selected, whose zinc intake levels fell within the recommended limits. These individuals were classified according to their smoking habits and hypertensive condition. A positive correlation was found (Pearson’s C = 0.639; p = 0.01) between Zn serum/urine quotient and oxidized glutathione levels (GSSG). Finally, risk of hypertension significantly increased when the GSSG levels exceeded the 75 percentile; OR = 2.80 (95%CI = 1.09–7.18) and AOR = 3.06 (95%CI = 0.96–9.71). Low zinc levels in serum were related with OS and cellular aging and were, in turn, to be a risk factor for hypertension. View Full-Text
Keywords: zinc; oxidative stress; hypertension; cellular aging zinc; oxidative stress; hypertension; cellular aging

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Morales-Suárez-Varela, M.; Llopis-González, A.; González-Albert, V.; López-Izquierdo, R.; González-Manzano, I.; Cháves, J.; Huerta-Biosca, V.; Martin-Escudero, J.C. Correlation of Zinc with Oxidative Stress Biomarkers. Int. J. Environ. Res. Public Health 2015, 12, 3060-3076.

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