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Open AccessArticle

Swinholide J, a Potent Cytotoxin from the Marine Sponge Theonella swinhoei

Department of Chemistry of Natural Compounds, University of Naples, “Federico II”, via D. Montesano 49, 80131 Napoli, Italy
Natural Substances Institute, la Terrasse Street, 91198 Gif sur Yvette Cedex, France
Polynesian Research Center on Island Biodiversity, UMR 7138 CNRS, B.P. 529, 98713 Papeete, Tahiti, French Polynesia, France
Author to whom correspondence should be addressed.
Mar. Drugs 2011, 9(6), 1133-1141;
Received: 23 May 2011 / Revised: 9 June 2011 / Accepted: 15 June 2011 / Published: 22 June 2011
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In our ongoing search for new pharmacologically active leads from Solomon organisms, we have examined the sponge Theonella swinhoei. Herein we report the isolation and structure elucidation of swinholide A (1) and one new macrolide, swinholide J (2). Swinholide J is an unprecedented asymmetric 44-membered dilactone with an epoxide functionality in half of the molecule. The structural determination was based on extensive interpretation of high-field NMR spectra and HRESIMS data. Swinholide J displayed potent in vitro cytotoxicity against KB cells (human nasopharynx cancer) with an IC50 value of 6 nM. View Full-Text
Keywords: marine cytotoxin; swinholide J; Theonella swinhoei marine cytotoxin; swinholide J; Theonella swinhoei
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Marino, S.D.; Festa, C.; D’Auria, M.V.; Cresteil, T.; Debitus, C.; Zampella, A. Swinholide J, a Potent Cytotoxin from the Marine Sponge Theonella swinhoei. Mar. Drugs 2011, 9, 1133-1141.

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