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Open AccessArticle

The Acute Toxicity and Hematological Characterization of the Effects of Tentacle-Only Extract from the Jellyfish Cyanea capillata

by Liang Xiao 1,†, Sihua Liu 1,†, Qian He 2,†, Qianqian Wang 1, Xuting Ye 3, Guoyan Liu 1, Fei Nie 1, Jie Zhao 1,* and Liming Zhang 1,*
1
Department of Chemical Defense Medicine, Faculty of Naval Medicine, Second Military Medical University, Shanghai 200433, China
2
Department of Gynecology and Obstetrics, Shanghai Hospital, Second Military Medical University, Shanghai 200433, China
3
Department of Biophysics, School of Basic Medical, Second Military Medical University, Shanghai 200433, China
*
Authors to whom correspondence should be addressed.
These authors contributed equally to the work.
Mar. Drugs 2011, 9(4), 526-534; https://doi.org/10.3390/md9040526
Received: 13 February 2011 / Revised: 14 March 2011 / Accepted: 25 March 2011 / Published: 29 March 2011
To investigate the hematologic changes and the activities of jellyfish venoms other than hemolytic and cardiovascular toxicities, the acute toxicity of tentacle-only extract (TOE) from the jellyfish Cyanea capillata was observed in mice, and hematological indexes were examined in rats. The median lethal dose (LD50) of TOE was 4.25 mg/kg, and the acute toxicity involved both heart- and nervous system-related symptoms. Arterial blood gas indexes, including pH, PCO2, HCO3, HCO3std, TCO2, BEecf and BE (B), decreased significantly. PO2 showed a slight increase, while SO2c (%) had no change at any time. Na+ and Ca2+ decreased, but K+ increased. Biochemical indexes, including LDH, CK, CK-MB, ALT, AST and sCr, significantly increased. Other biochemical indexes, including BUN and hemodiastase, remained normal. Lactic acid significantly increased, while glucose, Hct% and THbc showed slight temporary increases and then returned to normal. These results on the acute toxicity and hematological changes should improve our understanding of the in vivo pathophysiological effects of TOE from C. capillata and indicate that it may also have neurotoxicity, liver toxicity and muscular toxicity in addition to hemolytic and cardiovascular toxicities, but no kidney or pancreatic toxicity. View Full-Text
Keywords: jellyfish; Cyanea capillata; tentacle-only extract; LD50; toxic symptom; hematological jellyfish; Cyanea capillata; tentacle-only extract; LD50; toxic symptom; hematological
MDPI and ACS Style

Xiao, L.; Liu, S.; He, Q.; Wang, Q.; Ye, X.; Liu, G.; Nie, F.; Zhao, J.; Zhang, L. The Acute Toxicity and Hematological Characterization of the Effects of Tentacle-Only Extract from the Jellyfish Cyanea capillata. Mar. Drugs 2011, 9, 526-534.

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