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Open AccessArticle

Biological Activity of Volatiles from Marine and Terrestrial Bacteria

1
Institute of Organic Chemistry, University of Braunschweig—Institute of Technology, Hagenring 30, 38106 Braunschweig, Germany
2
Research Group Microbial Communication, Helmholtz Center for Infection Research, Inhoffenstrasse 7, 38124 Braunschweig, Germany
3
Department of Chemical Biology, Helmholtz Center for Infection Research, Inhoffenstrasse 7, 38124 Braunschweig, Germany
*
Author to whom correspondence should be addressed.
Mar. Drugs 2010, 8(12), 2976-2987; https://doi.org/10.3390/md8122976
Received: 12 November 2010 / Revised: 7 December 2010 / Accepted: 17 December 2010 / Published: 22 December 2010
The antiproliferative activity of 52 volatile compounds released from bacteria was investigated in agar diffusion assays against medically important microorganisms and mouse fibroblasts. Furthermore, the activity of these compounds to interfere with the quorum-sensing-systems was tested with two different reporter strains. While some of the compounds specific to certain bacteria showed some activity in the antiproliferative assay, the compounds common to many bacteria were mostly inactive. In contrast, some of these compounds were active in the quorum-sensing-tests. γ-Lactones showed a broad reactivity, while pyrazines seem to have only low intrinsic activity. A general discussion on the ecological importance of these findings is given. View Full-Text
Keywords: lactones; sulfur compounds; pyrazines; bacterial communication; quorum-sensing; ketones; aromatic compounds; agar diffusion assay; terpenes lactones; sulfur compounds; pyrazines; bacterial communication; quorum-sensing; ketones; aromatic compounds; agar diffusion assay; terpenes
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Schulz, S.; Dickschat, J.S.; Kunze, B.; Wagner-Dobler, I.; Diestel, R.; Sasse, F. Biological Activity of Volatiles from Marine and Terrestrial Bacteria. Mar. Drugs 2010, 8, 2976-2987.

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