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Marine Drugs
Volume 24
Issue 6
10.3390/md24060214
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This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Article

New Cytotoxic Anthraquinone Derivatives from a Deep-Sea-Derived Aspergillus sp. SCSIO 41331

by
Ziyi Wu
1,2,†,
Zehan Zheng
3,†,
Weimao Zhong
1,2,4,
Qianting Jiang
1,2,
Mengjing Cong
1,2,
Haozhe Zhang
3,
Fazuo Wang
1,2,4,
Yonghong Liu
1,2,4,
Hailiang Hu
3,* and
Junfeng Wang
1,2,4,*
1
State Key Laboratory of Tropical Oceanography, Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China
2
University of Chinese Academy of Sciences, 19 Yuquan Road, Beijing 100049, China
3
Department of Biochemistry, SUSTech Homeostatic Medicine Institute, School of Medicine, Southern University of Science and Technology, Shenzhen 518000, China
4
Sanya Institute of Ocean Eco-Environmental Engineering, Sanya 572000, China
*
Authors to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Mar. Drugs 2026, 24(6), 214; https://doi.org/10.3390/md24060214 (registering DOI)
Submission received: 25 April 2026 / Revised: 5 June 2026 / Accepted: 13 June 2026 / Published: 15 June 2026
(This article belongs to the Section Marine Biotechnology Related to Drug Discovery or Production)
Versions Notes

Abstract

Two new anthraquinone derivatives, (±)-1′-O-methyl-6-chloroaverantin (1a and 1b) and 6-chloroaverythrin (2), and one new diphenyl ether 1-((E)-but-2-en-2-yl)-3,8-dihydroxy-6-((E)-4-hydroxybut-2-en-2-yl)-4,9-dimethyl-11H-dibenzo[b,e][1,4]dioxepin-11-one (3), along with six known compounds, were isolated from the fungus Aspergillus sp. SCSIO 41331 collected from the deep-sea sediment in the cold-seep area of the South China Sea. Elucidation of planar structures was achieved via 1D and 2D NMR and mass spectrometry, whereas stereochemistry was validated through optical rotation and NOE correlations, chiral phase HPLC analysis and NMR calculation. All compounds were assessed for antitumor activity, among which compound 4 displayed moderate antiproliferative activity against HT29 cells and suppressed colony expansion.
Keywords: anthraquinone; diphenyl ether; deep-sea-derived fungi; anticancer activity anthraquinone; diphenyl ether; deep-sea-derived fungi; anticancer activity

Share and Cite

MDPI and ACS Style

Wu, Z.; Zheng, Z.; Zhong, W.; Jiang, Q.; Cong, M.; Zhang, H.; Wang, F.; Liu, Y.; Hu, H.; Wang, J. New Cytotoxic Anthraquinone Derivatives from a Deep-Sea-Derived Aspergillus sp. SCSIO 41331. Mar. Drugs 2026, 24, 214. https://doi.org/10.3390/md24060214

AMA Style

Wu Z, Zheng Z, Zhong W, Jiang Q, Cong M, Zhang H, Wang F, Liu Y, Hu H, Wang J. New Cytotoxic Anthraquinone Derivatives from a Deep-Sea-Derived Aspergillus sp. SCSIO 41331. Marine Drugs. 2026; 24(6):214. https://doi.org/10.3390/md24060214

Chicago/Turabian Style

Wu, Ziyi, Zehan Zheng, Weimao Zhong, Qianting Jiang, Mengjing Cong, Haozhe Zhang, Fazuo Wang, Yonghong Liu, Hailiang Hu, and Junfeng Wang. 2026. "New Cytotoxic Anthraquinone Derivatives from a Deep-Sea-Derived Aspergillus sp. SCSIO 41331" Marine Drugs 24, no. 6: 214. https://doi.org/10.3390/md24060214

APA Style

Wu, Z., Zheng, Z., Zhong, W., Jiang, Q., Cong, M., Zhang, H., Wang, F., Liu, Y., Hu, H., & Wang, J. (2026). New Cytotoxic Anthraquinone Derivatives from a Deep-Sea-Derived Aspergillus sp. SCSIO 41331. Marine Drugs, 24(6), 214. https://doi.org/10.3390/md24060214

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