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Marine Drugs
Volume 23
Issue 7
10.3390/md23070259
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This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Article

A Comparative Study of the Phytochemical Composition, Antioxidant Properties, and In Vitro Anti-Diabetic Efficacy of Different Extracts of Caulerpa prolifera

by
Safae Ouahabi
1,2,
Nour Elhouda Daoudi
2,3,
Mohamed Chebaibi
4,5,
Ibrahim Mssillou
6,
Ilyesse Rahhou
3,
Mohamed Bnouham
2,
Belkheir Hammouti
7,
Marie-Laure Fauconnier
8,
Alicia Ayerdi Gotor
9,*,
Larbi Rhazi
10 and
Mohammed Ramdani
11
1
Faculty of Medicine and Pharmacy of Oujda, Mohammed First University, 724, Oujda 60000, Morocco
2
Laboratory of Bioresources, Biotechnology, Ethnopharmacology and Health, Faculty of Sciences, Mohammed First University, BP 717, Oujda 60000, Morocco
3
Higher Institute of Nursing Professions and Health Techniques, Oujda 60000, Morocco
4
Ministry of Health and Social Protection, Higher Institute of Nursing Professions and Health Techniques, Fez 30000, Morocco
5
Biomedical and Translational Research Laboratory, Faculty of Medicine and Pharmacy of Fez, Sidi Mohamed Ben Abdellah University, Fez 30000, Morocco
6
National Agency of Medicinal and Aromatic Plants, BP 159, Principal, Taounate 34000, Morocco
7
Euromed Research Center, Euromed Polytechnic School, Euromed University of Fes (UEMF), Fes 30000, Morocco
8
Laboratory of Chemistry of Natural Molecules, University of Liège, Gembloux Agro-Bio Tech. 2, Passage des Déportés, B-5030 Gembloux, Belgium
9
Institut Polytechnique UniLaSalle, AGHYLE, UP 2018.C101, UniLaSalle, 19 rue Pierre Waguet, BP 30313, 60026 Beauvais, France
10
Institut Polytechnique UniLaSalle, Université d’Artois, ULR 7519, 19 Rue Pierre Waguet, BP 30313, 60026 Beauvais, France
11
Laboratory of Applied and Environmental Chemistry (LCAE), Faculty of Sciences, Mohammed First University, B.P. 717, Oujda 60000, Morocco
 
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Author to whom correspondence should be addressed.
Mar. Drugs 2025, 23(7), 259; https://doi.org/10.3390/md23070259 (registering DOI)
Submission received: 12 May 2025 / Revised: 18 June 2025 / Accepted: 19 June 2025 / Published: 21 June 2025
(This article belongs to the Special Issue Marine Algae: Exploring Their Nutritional, Health, and Nutraceutical Potential)
Versions Notes

Abstract

The Moroccan coastline has been the focus of attention for researchers studying the national algal flora, with the aim of preserving these invaluable natural resources. Since the year 2000, these resources have stimulated great interest in the creation of new drugs, as well as their integration into food supplements and foods. Therefore, this study aims to explore the phytochemistry of a series of extracts derived from Caulerpa prolifera. To ensure better extraction of the various metabolites present, two extraction methods, namely maceration and the Soxhlet method, were employed using solvents of varying polarity (hexane, ethyl acetate, methanol, and water). The chemical composition of the extracts was analyzed using GC-MS for fatty acids and HPLC-DAD for phenolic compounds. Antioxidant activity was evaluated using DPPH and β-carotene bleaching assays, while antidiabetic potential was assessed by in vitro inhibition of α-amylase and α-glucosidase. In addition, Molecular docking models were employed to assess the interaction between the bioactive molecules and the human pancreatic α-amylase and α-glucosidase enzymes. Vanillin, p-coumaric acid, sinapic acid, 7,3′,4′-flavon-3-ol, and kaempferol were the most abundant phenolic compounds. Anti-diabetic and antioxidant effects were highly significant.
Keywords: Caulerpa prolifera; fatty acids; phenolic compounds; antioxidant activity; anti-diabetic properties; enzyme inhibition Caulerpa prolifera; fatty acids; phenolic compounds; antioxidant activity; anti-diabetic properties; enzyme inhibition

Share and Cite

MDPI and ACS Style

Ouahabi, S.; Daoudi, N.E.; Chebaibi, M.; Mssillou, I.; Rahhou, I.; Bnouham, M.; Hammouti, B.; Fauconnier, M.-L.; Ayerdi Gotor, A.; Rhazi, L.; et al. A Comparative Study of the Phytochemical Composition, Antioxidant Properties, and In Vitro Anti-Diabetic Efficacy of Different Extracts of Caulerpa prolifera. Mar. Drugs 2025, 23, 259. https://doi.org/10.3390/md23070259

AMA Style

Ouahabi S, Daoudi NE, Chebaibi M, Mssillou I, Rahhou I, Bnouham M, Hammouti B, Fauconnier M-L, Ayerdi Gotor A, Rhazi L, et al. A Comparative Study of the Phytochemical Composition, Antioxidant Properties, and In Vitro Anti-Diabetic Efficacy of Different Extracts of Caulerpa prolifera. Marine Drugs. 2025; 23(7):259. https://doi.org/10.3390/md23070259

Chicago/Turabian Style

Ouahabi, Safae, Nour Elhouda Daoudi, Mohamed Chebaibi, Ibrahim Mssillou, Ilyesse Rahhou, Mohamed Bnouham, Belkheir Hammouti, Marie-Laure Fauconnier, Alicia Ayerdi Gotor, Larbi Rhazi, and et al. 2025. "A Comparative Study of the Phytochemical Composition, Antioxidant Properties, and In Vitro Anti-Diabetic Efficacy of Different Extracts of Caulerpa prolifera" Marine Drugs 23, no. 7: 259. https://doi.org/10.3390/md23070259

APA Style

Ouahabi, S., Daoudi, N. E., Chebaibi, M., Mssillou, I., Rahhou, I., Bnouham, M., Hammouti, B., Fauconnier, M.-L., Ayerdi Gotor, A., Rhazi, L., & Ramdani, M. (2025). A Comparative Study of the Phytochemical Composition, Antioxidant Properties, and In Vitro Anti-Diabetic Efficacy of Different Extracts of Caulerpa prolifera. Marine Drugs, 23(7), 259. https://doi.org/10.3390/md23070259

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