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Article

Extracellular Vesicles from Ecklonia cava and Phlorotannin Promote Rejuvenation in Aged Skin

1
Department of Anatomy & Cell Biology, College of Medicine, Gachon University, Incheon 21936, Republic of Korea
2
Functional Cellular Networks Laboratory, Graduate School and Lee Gil Ya Cancer and Diabetes Institute, Gachon University, Incheon 21999, Republic of Korea
3
Doctors Dermatologic Clinic, Gangdong Godeok, Seoul 05269, Republic of Korea
4
Glassy Skin Clinic, Seoul 06010, Republic of Korea
5
Department of Thoracic and Cardiovascular Surgery, Gachon University Gil Medical Center, Gachon University, Incheon 21565, Republic of Korea
6
Department of Health Sciences and Technology, Gachon Advanced Institute for Health & Sciences and Technology (GAIHST), Gachon University, Incheon 21999, Republic of Korea
*
Authors to whom correspondence should be addressed.
Mar. Drugs 2024, 22(5), 223; https://doi.org/10.3390/md22050223
Submission received: 2 February 2024 / Revised: 7 May 2024 / Accepted: 14 May 2024 / Published: 15 May 2024
(This article belongs to the Section Marine Pharmacology)

Abstract

Plant-derived extracellular vesicles (EVs) elicit diverse biological effects, including promoting skin health. EVs isolated from Ecklonia cava (EV-EC) carry heat shock protein 70 (HSP70), which inhibits key regulators such as TNF-α, MAPKs, and NF-κB, consequently downregulating matrix metalloproteinases (MMPs). Aging exacerbates oxidative stress, upregulating MAPK and NF-κB signaling and worsening extracellular matrix degradation in the skin. E. cava-derived phlorotannin (PT) mitigates MAPK and NF-κB signaling. We evaluated the impact of EV-EC and PT on skin rejuvenation using an in vitro keratinocyte senescence model and an in vivo aged-mouse model. Western blotting confirmed the presence of HSP70 in EV-EC. Treatment with EV-EC and PT in senescent keratinocytes increased HSP70 expression and decreased the expression of TNF-α, MAPK, NF-κB, activator protein-1 (AP-1), and MMPs. Oxidative stress was also reduced. Sequential treatment with PT and EV-EC (PT/EV-EC) yielded more significant results compared to individual treatments. The administration of PT/EV-EC to the back skin of aged mice mirrored the in vitro findings, resulting in increased collagen fiber accumulation and improved elasticity in the aged skin. Therefore, PT/EV-EC holds promise in promoting skin rejuvenation by increasing HSP70 expression, decreasing the expression of MMPs, and reducing oxidative stress in aged skin.
Keywords: Ecklonia cava; extracellular vesicles from Ecklonia cava; phlorotannin; skin rejuvenation Ecklonia cava; extracellular vesicles from Ecklonia cava; phlorotannin; skin rejuvenation

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MDPI and ACS Style

Batsukh, S.; Oh, S.; Lee, J.M.; Joo, J.H.J.; Son, K.H.; Byun, K. Extracellular Vesicles from Ecklonia cava and Phlorotannin Promote Rejuvenation in Aged Skin. Mar. Drugs 2024, 22, 223. https://doi.org/10.3390/md22050223

AMA Style

Batsukh S, Oh S, Lee JM, Joo JHJ, Son KH, Byun K. Extracellular Vesicles from Ecklonia cava and Phlorotannin Promote Rejuvenation in Aged Skin. Marine Drugs. 2024; 22(5):223. https://doi.org/10.3390/md22050223

Chicago/Turabian Style

Batsukh, Sosorburam, Seyeon Oh, Ji Min Lee, Judy Hong Jin Joo, Kuk Hui Son, and Kyunghee Byun. 2024. "Extracellular Vesicles from Ecklonia cava and Phlorotannin Promote Rejuvenation in Aged Skin" Marine Drugs 22, no. 5: 223. https://doi.org/10.3390/md22050223

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