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Marine Drugs
Volume 20
Issue 9
10.3390/md20090557
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Article

Anti-Melanogenesis and Photoprotective Effects of Ecklonia maxima Extract Containing Dieckol and Eckmaxol

by
Lei Wang
1,
Jun-Geon Je
2,
Hyun-Soo Kim
3,
Kaiqiang Wang
1,
Xiaoting Fu
1,
Jiachao Xu
1,
Xin Gao
1 and
You-Jin Jeon
2,4,*
1
College of Food Science and Engineering, Ocean University of China, Qingdao 266003, China
2
Department of Marine Life Sciences, Jeju National University, Jeju 63243, Korea
3
National Marine Biodiversity Institute of Korea, Seocheon 33677, Korea
4
Marine Science Institute, Jeju National University, Jeju 63333, Korea
*
Author to whom correspondence should be addressed.
Mar. Drugs 2022, 20(9), 557; https://doi.org/10.3390/md20090557
Submission received: 24 July 2022 / Revised: 23 August 2022 / Accepted: 29 August 2022 / Published: 30 August 2022
(This article belongs to the Special Issue Advances in Medicinal Research of Phlorotannins)
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Abstract

Seaweeds are potential ingredients in the cosmeceutical industry. Our previous study demonstrates that the phlorotannin-enriched extract of Ecklonia maxima (EME-EA) containing dieckol and eckmaxol possesses strong anti-inflammatory activity and suggests the cosmeceutical potential of EME-EA. In order to evaluate the cosmeceutical potential of EME-EA, the anti-melanogenesis and photoprotective effects of EME-EA were investigated in this study. EME-EA remarkably inhibited mushroom tyrosinase and melanogenesis in alpha-melanocyte-stimulating hormone-stimulated B16F10 cells. In addition, EME-EA significantly suppressed UVB-induced HaCaT cell death that was consistent with inhibition of apoptosis and reduction in scavenging intracellular reactive oxygen species. Furthermore, EME-EA significantly inhibited collagen degradation and matrix metalloproteinases expression in UVB-irradiated HDF cells in a concentration-dependent manner. These results indicate that EME-EA possesses strong anti-melanogenesis and photoprotective activities and suggest EME-EA is an ideal ingredient in the pharmaceutical and cosmeceutical industries.
Keywords: Ecklonia maxima; melanogenesis; UVB irradiation; photodamage Ecklonia maxima; melanogenesis; UVB irradiation; photodamage

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MDPI and ACS Style

Wang, L.; Je, J.-G.; Kim, H.-S.; Wang, K.; Fu, X.; Xu, J.; Gao, X.; Jeon, Y.-J. Anti-Melanogenesis and Photoprotective Effects of Ecklonia maxima Extract Containing Dieckol and Eckmaxol. Mar. Drugs 2022, 20, 557. https://doi.org/10.3390/md20090557

AMA Style

Wang L, Je J-G, Kim H-S, Wang K, Fu X, Xu J, Gao X, Jeon Y-J. Anti-Melanogenesis and Photoprotective Effects of Ecklonia maxima Extract Containing Dieckol and Eckmaxol. Marine Drugs. 2022; 20(9):557. https://doi.org/10.3390/md20090557

Chicago/Turabian Style

Wang, Lei, Jun-Geon Je, Hyun-Soo Kim, Kaiqiang Wang, Xiaoting Fu, Jiachao Xu, Xin Gao, and You-Jin Jeon. 2022. "Anti-Melanogenesis and Photoprotective Effects of Ecklonia maxima Extract Containing Dieckol and Eckmaxol" Marine Drugs 20, no. 9: 557. https://doi.org/10.3390/md20090557

APA Style

Wang, L., Je, J.-G., Kim, H.-S., Wang, K., Fu, X., Xu, J., Gao, X., & Jeon, Y.-J. (2022). Anti-Melanogenesis and Photoprotective Effects of Ecklonia maxima Extract Containing Dieckol and Eckmaxol. Marine Drugs, 20(9), 557. https://doi.org/10.3390/md20090557

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