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Marine Drugs
Volume 20
Issue 8
10.3390/md20080483
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Article

Preventive and Therapeutic Effects of Krill Oil on Obesity and Obesity-Induced Metabolic Syndromes in High-Fat Diet-Fed Mice

by
Seung-Min Hwang
1,†,
Yeong Uk Kim
2,†,
Jong-Kyu Kim
3,
Yoon-Seok Chun
3,
Young-Sam Kwon
1,
Sae-Kwang Ku
4,* and
Chang-Hyun Song
4,*
1
Department of Veterinary Surgery, College of Veterinary Medicine, Kyungpook National University, Daegu 41566, Korea
2
Department of Urology, College of Medicine, Yeungnam University, Daegu 42415, Korea
3
AriBnC Co., Ltd., Yongin 16914, Korea
4
Department of Anatomy and Histology, College of Korean Medicine, Daegu Haany University, Gyeongsan 38610, Korea
*
Authors to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Mar. Drugs 2022, 20(8), 483; https://doi.org/10.3390/md20080483
Submission received: 23 June 2022 / Revised: 18 July 2022 / Accepted: 25 July 2022 / Published: 27 July 2022
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Abstract

Obesity increases the risks of metabolic syndromes including nonalcoholic fatty liver disease (NAFLD), diabetic dyslipidemia, and chronic kidney disease. Dietary krill oil (KO) has shown antioxidant and anti-inflammatory properties, thereby being a therapeutic potential for obesity-induced metabolic syndromes. Thus, the effects of KO on lipid metabolic alteration were examined in a high-fat diet (HFD)-fed mice model. The HFD model (n = 10 per group) received an oral gavage with distilled water as a control, metformin at 250 mg/kg, and KO at 400, 200, and 100 mg/kg for 12 weeks. The HFD-induced weight gain and fat deposition were significantly reduced in the KO treatments compared with the control. Blood levels were lower in parameters for NAFLD (e.g., alanine aminotransferase, and triglyceride), type 2 diabetes (e.g., glucose and insulin), and renal dysfunction (e.g., blood urea nitrogen and creatinine) by the KO treatments. The KO inhibited lipid synthesis through the modification of gene expressions in the liver and adipose tissues and adipokine-mediated pathways. Furthermore, KO showed hepatic antioxidant activities and glucose lowering effects. Histopathological analyses revealed that the KO ameliorated the hepatic steatosis, pancreatic endocrine/exocrine alteration, adipose tissue hypertrophy, and renal steatosis. These analyses suggest that KO may be promising for inhibiting obesity and metabolic syndromes.
Keywords: obesity; diabetes; NAFLD; T2D; dyslipidemia; HFD; steatosis; metformin; marine; PUFA obesity; diabetes; NAFLD; T2D; dyslipidemia; HFD; steatosis; metformin; marine; PUFA

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MDPI and ACS Style

Hwang, S.-M.; Kim, Y.U.; Kim, J.-K.; Chun, Y.-S.; Kwon, Y.-S.; Ku, S.-K.; Song, C.-H. Preventive and Therapeutic Effects of Krill Oil on Obesity and Obesity-Induced Metabolic Syndromes in High-Fat Diet-Fed Mice. Mar. Drugs 2022, 20, 483. https://doi.org/10.3390/md20080483

AMA Style

Hwang S-M, Kim YU, Kim J-K, Chun Y-S, Kwon Y-S, Ku S-K, Song C-H. Preventive and Therapeutic Effects of Krill Oil on Obesity and Obesity-Induced Metabolic Syndromes in High-Fat Diet-Fed Mice. Marine Drugs. 2022; 20(8):483. https://doi.org/10.3390/md20080483

Chicago/Turabian Style

Hwang, Seung-Min, Yeong Uk Kim, Jong-Kyu Kim, Yoon-Seok Chun, Young-Sam Kwon, Sae-Kwang Ku, and Chang-Hyun Song. 2022. "Preventive and Therapeutic Effects of Krill Oil on Obesity and Obesity-Induced Metabolic Syndromes in High-Fat Diet-Fed Mice" Marine Drugs 20, no. 8: 483. https://doi.org/10.3390/md20080483

APA Style

Hwang, S.-M., Kim, Y. U., Kim, J.-K., Chun, Y.-S., Kwon, Y.-S., Ku, S.-K., & Song, C.-H. (2022). Preventive and Therapeutic Effects of Krill Oil on Obesity and Obesity-Induced Metabolic Syndromes in High-Fat Diet-Fed Mice. Marine Drugs, 20(8), 483. https://doi.org/10.3390/md20080483

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