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Possible Functional Roles of Patellamides in the Ascidian-Prochloron Symbiosis

by 1,2, 3,*, 1,2,4,* and 5,*
1
Institute of Inorganic Chemistry, Heidelberg University, Im Neuenheimer Feld 270, 69120 Heidelberg, Germany
2
Max Planck School Matter to Life, 69120 Heidelberg, Germany
3
Marine Biology Section, Department of Biology, University of Copenhagen, Strandpromenaden 5, DK-3000 Helsingør, Denmark
4
Interdisciplinary Center of Scientific Computing, Heidelberg University, 69120 Heidelberg, Germany
5
Department of Organismal Biology, Science for Life Laboratory, Uppsala University, Norbyvägen 18 A, 752 36 Uppsala, Sweden
*
Authors to whom correspondence should be addressed.
Academic Editor: Jean-Baptiste Raina
Mar. Drugs 2022, 20(2), 119; https://doi.org/10.3390/md20020119
Received: 20 December 2021 / Revised: 27 January 2022 / Accepted: 27 January 2022 / Published: 2 February 2022
(This article belongs to the Special Issue Bioactive Compounds from Coral Reef Organisms 2021)
Patellamides are highly bioactive compounds found along with other cyanobactins in the symbiosis between didemnid ascidians and the enigmatic cyanobacterium Prochloron. The biosynthetic pathway of patellamide synthesis is well understood, the relevant operons have been identified in the Prochloron genome and genes involved in patellamide synthesis are among the most highly transcribed cyanobacterial genes in hospite. However, a more detailed study of the in vivo dynamics of patellamides and their function in the ascidian-Prochloron symbiosis is complicated by the fact that Prochloron remains uncultivated despite numerous attempts since its discovery in 1975. A major challenge is to account for the highly dynamic microenvironmental conditions experienced by Prochloron in hospite, where light-dark cycles drive rapid shifts between hyperoxia and anoxia as well as pH variations from pH ~6 to ~10. Recently, work on patellamide analogues has pointed out a range of different catalytic functions of patellamide that could prove essential for the ascidian-Prochloron symbiosis and could be modulated by the strong microenvironmental dynamics. Here, we review fundamental properties of patellamides and their occurrence and dynamics in vitro and in vivo. We discuss possible functions of patellamides in the ascidian-Prochloron symbiosis and identify important knowledge gaps and needs for further experimental studies. View Full-Text
Keywords: patellamide; cyanobactin; symbiosis; Prochloron; didemnid ascidians patellamide; cyanobactin; symbiosis; Prochloron; didemnid ascidians
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MDPI and ACS Style

Baur, P.; Kühl, M.; Comba, P.; Behrendt, L. Possible Functional Roles of Patellamides in the Ascidian-Prochloron Symbiosis. Mar. Drugs 2022, 20, 119. https://doi.org/10.3390/md20020119

AMA Style

Baur P, Kühl M, Comba P, Behrendt L. Possible Functional Roles of Patellamides in the Ascidian-Prochloron Symbiosis. Marine Drugs. 2022; 20(2):119. https://doi.org/10.3390/md20020119

Chicago/Turabian Style

Baur, Philipp, Michael Kühl, Peter Comba, and Lars Behrendt. 2022. "Possible Functional Roles of Patellamides in the Ascidian-Prochloron Symbiosis" Marine Drugs 20, no. 2: 119. https://doi.org/10.3390/md20020119

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