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Article

Diet Supplementation with Fish-Derived Extracts Suppresses Diabetes and Modulates Intestinal Microbiome in a Murine Model of Diet-Induced Obesity

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Laboratory of Clinical Chemistry, Medical School, University of Crete, 70013 Heraklion, Greece
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Institute of Molecular Biology and Biotechnology, FORTH, 71100 Heraklion, Greece
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Institute of Applied Biosciences (INAB), CERTH, Thermi, 57001 Thessaloniki, Greece
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Department of Nutrition and Feed Technology, Nofima AS, 5141 Bergen, Norway
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Department of Food Science and Nutrition, University of the Aegean, Myrina, 81400 Lemnos, Greece
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Seagarden AS, 4262 Avaldsnes, Norway
*
Authors to whom correspondence should be addressed.
Academic Editor: Marialuisa Menna
Mar. Drugs 2021, 19(5), 268; https://doi.org/10.3390/md19050268
Received: 13 April 2021 / Revised: 29 April 2021 / Accepted: 7 May 2021 / Published: 11 May 2021
(This article belongs to the Special Issue Marine Natural Products Modulating the Immune System)
Metabolic syndrome-related diseases affect millions of people worldwide. It is well established that changes in nutritional habits and lifestyle can improve or prevent metabolic-related pathologies such as type-2 diabetes and obesity. Previous reports have shown that nutritional supplements have the capacity to limit glucose intolerance and suppress diabetes development. In this study, we investigated the effect of dietary supplementation with fish-derived extracts on obesity and type 2 diabetes and their impact on gut microbial composition. We showed that nutritional supplements containing Fish Complex (FC), Fish Complex combined with Cod Powder (FC + CP), or Cod Powder combined with Collagen (CP + C) improved glucose intolerance, independent of abdominal fat accumulation, in a mouse model of diet-induced obesity and type 2 diabetes. In addition, collagen-containing supplements distinctly modulate the gut microbiome in high-fat induced obesity in mice. Our results suggest that fish-derived supplements suppress diet-induced type 2 diabetes, which may be partly mediated through changes in the gut microbiome. Thus, fish-derived supplements and particularly the ones containing fish collagen have potential beneficial properties as dietary supplements in managing type 2 diabetes and metabolic syndrome via modulation of the gut microbiome. View Full-Text
Keywords: obesity; type 2 diabetes; insulin resistance; fish extract; collagen; gut microbiome obesity; type 2 diabetes; insulin resistance; fish extract; collagen; gut microbiome
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MDPI and ACS Style

Axarlis, K.; Daskalaki, M.G.; Michailidou, S.; Androulaki, N.; Tsoureki, A.; Mouchtaropoulou, E.; Kolliniati, O.; Lapi, I.; Dermitzaki, E.; Venihaki, M.; Kousoulaki, K.; Argiriou, A.; Marsni, Z.E.; Tsatsanis, C. Diet Supplementation with Fish-Derived Extracts Suppresses Diabetes and Modulates Intestinal Microbiome in a Murine Model of Diet-Induced Obesity. Mar. Drugs 2021, 19, 268. https://doi.org/10.3390/md19050268

AMA Style

Axarlis K, Daskalaki MG, Michailidou S, Androulaki N, Tsoureki A, Mouchtaropoulou E, Kolliniati O, Lapi I, Dermitzaki E, Venihaki M, Kousoulaki K, Argiriou A, Marsni ZE, Tsatsanis C. Diet Supplementation with Fish-Derived Extracts Suppresses Diabetes and Modulates Intestinal Microbiome in a Murine Model of Diet-Induced Obesity. Marine Drugs. 2021; 19(5):268. https://doi.org/10.3390/md19050268

Chicago/Turabian Style

Axarlis, Konstantinos, Maria G. Daskalaki, Sofia Michailidou, Nikolais Androulaki, Antiopi Tsoureki, Evangelia Mouchtaropoulou, Ourania Kolliniati, Ioanna Lapi, Eirini Dermitzaki, Maria Venihaki, Katerina Kousoulaki, Anagnostis Argiriou, Zouhir E. Marsni, and Christos Tsatsanis. 2021. "Diet Supplementation with Fish-Derived Extracts Suppresses Diabetes and Modulates Intestinal Microbiome in a Murine Model of Diet-Induced Obesity" Marine Drugs 19, no. 5: 268. https://doi.org/10.3390/md19050268

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