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Marine Drugs
Volume 19
Issue 10
10.3390/md19100572
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Review

Research Progress in Anti-Inflammatory Bioactive Substances Derived from Marine Microorganisms, Sponges, Algae, and Corals

by
Chao-Qun Li
1,
Qin-Yuan Ma
1,
Xiu-Zhen Gao
1,
Xuan Wang
2,3 and
Bei-Li Zhang
1,*
1
School of Life Sciences and Medicine, Shandong University of Technology, Zibo 255000, China
2
Key Laboratory of Mariculture (Ministry of Education), Fisheries College, Ocean University of China, Qingdao 266003, China
3
Key Laboratory of Aquaculture Nutrition and Feed, Ministry of Agriculture, Ocean University of China, Qingdao 266003, China
*
Author to whom correspondence should be addressed.
Mar. Drugs 2021, 19(10), 572; https://doi.org/10.3390/md19100572
Submission received: 12 September 2021 / Revised: 4 October 2021 / Accepted: 10 October 2021 / Published: 14 October 2021
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Abstract

Inflammation is the body’s defense reaction in response to stimulations and is the basis of various physiological and pathological processes. However, chronic inflammation is undesirable and closely related to the occurrence and development of diseases. The ocean gives birth to unique and diverse bioactive substances, which have gained special attention and been a focus for anti-inflammatory drug development. So far, numerous promising bioactive substances have been obtained from various marine organisms such as marine bacteria and fungi, sponges, algae, and coral. This review covers 71 bioactive substances described during 2015–2020, including the structures (65 of which), species sources, evaluation models and anti-inflammatory activities of these substances. This review aims to provide some reference for the research progress of marine-organism-derived anti-inflammatory metabolites and give more research impetus for their conversion to novel anti-inflammatory drugs.
Keywords: anti-inflammatory activity; inflammatory pathways; natural product; marine bacteria and fungi; marine algae; sponge; coral anti-inflammatory activity; inflammatory pathways; natural product; marine bacteria and fungi; marine algae; sponge; coral

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MDPI and ACS Style

Li, C.-Q.; Ma, Q.-Y.; Gao, X.-Z.; Wang, X.; Zhang, B.-L. Research Progress in Anti-Inflammatory Bioactive Substances Derived from Marine Microorganisms, Sponges, Algae, and Corals. Mar. Drugs 2021, 19, 572. https://doi.org/10.3390/md19100572

AMA Style

Li C-Q, Ma Q-Y, Gao X-Z, Wang X, Zhang B-L. Research Progress in Anti-Inflammatory Bioactive Substances Derived from Marine Microorganisms, Sponges, Algae, and Corals. Marine Drugs. 2021; 19(10):572. https://doi.org/10.3390/md19100572

Chicago/Turabian Style

Li, Chao-Qun, Qin-Yuan Ma, Xiu-Zhen Gao, Xuan Wang, and Bei-Li Zhang. 2021. "Research Progress in Anti-Inflammatory Bioactive Substances Derived from Marine Microorganisms, Sponges, Algae, and Corals" Marine Drugs 19, no. 10: 572. https://doi.org/10.3390/md19100572

APA Style

Li, C.-Q., Ma, Q.-Y., Gao, X.-Z., Wang, X., & Zhang, B.-L. (2021). Research Progress in Anti-Inflammatory Bioactive Substances Derived from Marine Microorganisms, Sponges, Algae, and Corals. Marine Drugs, 19(10), 572. https://doi.org/10.3390/md19100572

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