Next Article in Journal
Characterization of the CAZy Repertoire from the Marine-Derived Fungus Stemphylium lucomagnoense in Relation to Saline Conditions
Previous Article in Journal
Astaxanthin and other Nutrients from Haematococcus pluvialis—Multifunctional Applications
Previous Article in Special Issue
Algae Metabolites in Cosmeceutical: An Overview of Current Applications and Challenges
Article

Marine Fungus Aspergillus chevalieri TM2-S6 Extract Protects Skin Fibroblasts from Oxidative Stress

1
Laboratory of Biochemistry, Research and Development Department, APIVITA S.A., Industrial Park of Markopoulo Mesogaias, Markopoulo Attiki, 19003 Athens, Greece
2
Institut de Chimie des Substances Naturelles ICSN, Centre National de la Recherche Scientifique CNRS, Avenue de la Terrasse, 91198 Gif-sur-Yvette, France
3
School of Zoology, George S. Wise Faculty of Life Sciences, Tel Aviv University, Ramat Aviv, Tel Aviv 69978, Israel
*
Authors to whom correspondence should be addressed.
Mar. Drugs 2020, 18(9), 460; https://doi.org/10.3390/md18090460
Received: 16 July 2020 / Revised: 29 August 2020 / Accepted: 4 September 2020 / Published: 8 September 2020
(This article belongs to the Special Issue Marine-Derived Ingredients for Cosmeceuticals)
The strain Aspergillus chevalieri TM2-S6 was isolated from the sponge Axinella and identified according to internal transcribed spacer (ITS) molecular sequence homology with Aspergillus species from the section Restricti. The strain was cultivated 9 days on potato dextrose broth (PDB), and the medium evaluated as antioxidant on primary normal human dermal fibroblasts (NHDF). The cultivation broth was submitted to sterile filtration, lyophilized and used without any further processing to give the Aspergillus chevalieri TM2-S6 cultivation broth ingredient named ACBB. ACCB contains two main compounds: tetrahydroauroglaucin and flavoglaucin. Under oxidative stress, ACCB showed a significant promotion of cell viability. To elucidate the mechanism of action, the impact on a panel of hundreds of genes involved in fibroblast physiology was evaluated. Thus, ACCB stimulates cell proliferation (VEGFA, TGFB3), antioxidant response (GPX1, SOD1, NRF2), and extracellular matrix organization (COL1A1, COL3A1, CD44, MMP14). ACCD also reduced aging (SIRT1, SIRT2, FOXO3). These findings indicate that Aspergillus chevalieri TM2-S6 cultivation broth exhibits significant in vitro skin protection of human fibroblasts under oxidative stress, making it a potential cosmetic ingredient. View Full-Text
Keywords: Aspergillus chevalieri; marine fungi; marine cosmetic ingredient; fibroblast protection; oxidative stress Aspergillus chevalieri; marine fungi; marine cosmetic ingredient; fibroblast protection; oxidative stress
Show Figures

Graphical abstract

MDPI and ACS Style

Letsiou, S.; Bakea, A.; Goff, G.L.; Lopes, P.; Gardikis, K.; Weis, M.; Benayahu, Y.; Ouazzani, J. Marine Fungus Aspergillus chevalieri TM2-S6 Extract Protects Skin Fibroblasts from Oxidative Stress. Mar. Drugs 2020, 18, 460. https://doi.org/10.3390/md18090460

AMA Style

Letsiou S, Bakea A, Goff GL, Lopes P, Gardikis K, Weis M, Benayahu Y, Ouazzani J. Marine Fungus Aspergillus chevalieri TM2-S6 Extract Protects Skin Fibroblasts from Oxidative Stress. Marine Drugs. 2020; 18(9):460. https://doi.org/10.3390/md18090460

Chicago/Turabian Style

Letsiou, Sophia; Bakea, Artemis; Goff, Géraldine L.; Lopes, Philippe; Gardikis, Konstantinos; Weis, Michal; Benayahu, Yehuda; Ouazzani, Jamal. 2020. "Marine Fungus Aspergillus chevalieri TM2-S6 Extract Protects Skin Fibroblasts from Oxidative Stress" Mar. Drugs 18, no. 9: 460. https://doi.org/10.3390/md18090460

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop