Preparation and Neuroprotective Activity of Glucuronomannan Oligosaccharides in an MPTP-Induced Parkinson’s Model
1
Key Laboratory of Experimental Marine Biology, Center for Ocean Mega-Science, Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China
2
Laboratory for Marine Biology and Biotechnology, Qingdao National Laboratory for Marine Science and Technology, Qingdao 266071, China
3
University of the Chinese Academy of Sciences, Beijing 100049, China
4
College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou 310014, China
*
Author to whom correspondence should be addressed.
Mar. Drugs 2020, 18(9), 438; https://doi.org/10.3390/md18090438
Received: 9 June 2020
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Revised: 14 August 2020
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Accepted: 18 August 2020
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Published: 23 August 2020
(This article belongs to the Special Issue Marine Natural Products against Brain Diseases and Injuries)
Parkinson’s disease (PD), characterized by dopaminergic neuron degeneration in the substantia nigra and dopamine depletion in the striatum, affects up to 1% of the global population over 50 years of age. Our previous study found that a heteropolysaccharide from Saccharina japonica exhibits neuroprotective effects through antioxidative stress. In view of its high molecular weight and complex structure, we degraded the polysaccharide and subsequently obtained four oligosaccharides. In this study, we aimed to further detect the neuroprotective mechanism of the oligosaccharides. We applied MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) to induce PD, and glucuronomannan oligosaccharides (GMn) was subsequently administered. Results showed that GMn ameliorated behavioral deficits in Parkinsonism mice. Furthermore, we observed that glucuronomannan oligosaccharides contributed to down-regulating the apoptotic signaling pathway through enhancing the expression of tyrosine hydroxylase (TH) in dopaminergic neurons. These results suggest that glucuronomannan oligosaccharides protect dopaminergic neurons from apoptosis in PD mice.
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MDPI and ACS Style
Liu, Y.; Jin, W.; Deng, Z.; Wang, J.; Zhang, Q. Preparation and Neuroprotective Activity of Glucuronomannan Oligosaccharides in an MPTP-Induced Parkinson’s Model. Mar. Drugs 2020, 18, 438. https://doi.org/10.3390/md18090438
AMA Style
Liu Y, Jin W, Deng Z, Wang J, Zhang Q. Preparation and Neuroprotective Activity of Glucuronomannan Oligosaccharides in an MPTP-Induced Parkinson’s Model. Marine Drugs. 2020; 18(9):438. https://doi.org/10.3390/md18090438
Chicago/Turabian StyleLiu, Yingjuan, Weihua Jin, Zhenzhen Deng, Jing Wang, and Quanbin Zhang. 2020. "Preparation and Neuroprotective Activity of Glucuronomannan Oligosaccharides in an MPTP-Induced Parkinson’s Model" Marine Drugs 18, no. 9: 438. https://doi.org/10.3390/md18090438
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