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Open AccessArticle

OctoPartenopin: Identification and Preliminary Characterization of a Novel Antimicrobial Peptide from the Suckers of Octopus vulgaris

1
Department of Biology, University of Naples “Federico II”, via Cinthia, 80126 Naples, Italy
2
Proteomics & Mass Spectrometry Laboratory, ISPAAM, National Research Council, 80147 Naples, Italy
3
Department of Agricultural Science, University of Naples “Federico II”, Via dell’Università 100, 80055 Naples, Italy
4
Department of Chemical Sciences, University of Naples “Federico II”, via Cinthia, 80126 Naples, Italy
5
Department of Pharmacy, University of Naples “Federico II”, Via Mezzocannone 16, 80134 Naples, Italy
*
Authors to whom correspondence should be addressed.
Mar. Drugs 2020, 18(8), 380; https://doi.org/10.3390/md18080380
Received: 9 June 2020 / Revised: 3 July 2020 / Accepted: 21 July 2020 / Published: 23 July 2020
Microorganism resistance to conventional antibiotics represents one of the major global health concerns. This paper focuses on a peptide (OctoPartenopin) extracted from suckers of Octopus vulgaris; bioassay-guided chromatographic fractionation was used to identify this sequence, which holds significant antibacterial activity against Gram-positive and Gram-negative bacteria. OctoPartenopin is encrypted within the calponin sequence and was associated with the high levels of proteolytic activity already reported in octopus arm suckers. We synthesized the parent peptide and four analogues; all peptide were tested for their antibacterial and antibiofilm activities. Preliminary antibiofilm experiments showed that that one of the analogues had the best activity in both inhibition and eradication of biofilm of all three microorganisms tested. The occurrence of OctoPartenopin in arm suckers provided novel speculative information on animal behavior, as concerns maternal care of fertilized eggs. Our results highlight that suckers are a rich source of multifaceted peptides to develop alternative antimicrobial agents and food preservatives. View Full-Text
Keywords: Octopus vulgaris; antimicrobial peptides; antimicrobial activity; antibiofilm activity Octopus vulgaris; antimicrobial peptides; antimicrobial activity; antibiofilm activity
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MDPI and ACS Style

Maselli, V.; Galdiero, E.; Salzano, A.M.; Scaloni, A.; Maione, A.; Falanga, A.; Naviglio, D.; Guida, M.; Di Cosmo, A.; Galdiero, S. OctoPartenopin: Identification and Preliminary Characterization of a Novel Antimicrobial Peptide from the Suckers of Octopus vulgaris. Mar. Drugs 2020, 18, 380.

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