Next Article in Journal
Functionalization of 3D Chitinous Skeletal Scaffolds of Sponge Origin Using Silver Nanoparticles and Their Antibacterial Properties
Previous Article in Journal
Light-Mediated Toxicity of Porphyrin-Like Pigments from a Marine Polychaeta
Open AccessArticle

Highly Oxygenated Constituents from a Marine Alga-Derived Fungus Aspergillus giganteus NTU967

1
Faculty of Pharmacy, School of Pharmaceutical Sciences, National Yang-Ming University, Taipei 11221, Taiwan
2
Department of Medical Research, China Medical University Hospital, China Medical University, Taichung 404, Taiwan
3
Department of Medicine, Mackay Medical College, New Taipei City 25245, Taiwan
4
Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 80708, Taiwan
5
Biodiversity Research Center, Academia Sinica, Taipei 11529, Taiwan
6
Institute of Marine Biology and Center of Excellence for the Oceans, National Taiwan Ocean University, Keelung 20224, Taiwan
7
Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, Taichung 40447, Taiwan
8
Department of Biotechnology, Asia University, Taichung 41354, Taiwan
9
Chinese Medical Research Center, China Medical University, Taichung 40447, Taiwan
10
Institute of Fisheries Science, National Taiwan University, Taipei 10617, Taiwan
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Mar. Drugs 2020, 18(6), 303; https://doi.org/10.3390/md18060303
Received: 9 May 2020 / Revised: 26 May 2020 / Accepted: 4 June 2020 / Published: 6 June 2020
Agar-based disc diffusion antimicrobial assay has shown that the ethyl acetate extract of the fermented broth of Aspergillus giganteus NTU967 isolated from Ulva lactuca exhibited significant antimicrobial activity in our preliminary screening of bioactive fungal strains. Therefore, column chromatography of the active principles from liquid- and solid–state fermented products of the fungal strain was carried out, and which had led to isolation of eleven compounds. Their structures were determined by spectral analysis to be seven new highly oxygenated polyketides, namely aspergilsmins A–G (17), along with previously reported patulin, deoxytryptoquivaline, tryptoquivaline and quinadoline B. Among these, aspergilsmin C (3) and patulin displayed promising anticancer activities against human hepatocellular carcinoma SK-Hep-1 cells and prostate cancer PC-3 cells with IC50 values between 2.7–7.3 μM. Furthermore, aspergilsmin C (3) and patulin exhibited significant anti-angiogenic functions by impeding cell growth and tube formation of human endothelial progenitor cells without any cytotoxicity. View Full-Text
Keywords: Aspergillus giganteus; Trichocomaceae; bioactive natural products; Polyketides; aspergilsmin Aspergillus giganteus; Trichocomaceae; bioactive natural products; Polyketides; aspergilsmin
Show Figures

Figure 1

MDPI and ACS Style

Chen, J.-J.; Wang, S.-W.; Chiang, Y.-R.; Pang, K.-L.; Kuo, Y.-H.; Shih, T.-Y.; Lee, T.-H. Highly Oxygenated Constituents from a Marine Alga-Derived Fungus Aspergillus giganteus NTU967. Mar. Drugs 2020, 18, 303.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop