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Open AccessArticle

Highly Oxygenated Constituents from a Marine Alga-Derived Fungus Aspergillus giganteus NTU967

Faculty of Pharmacy, School of Pharmaceutical Sciences, National Yang-Ming University, Taipei 11221, Taiwan
Department of Medical Research, China Medical University Hospital, China Medical University, Taichung 404, Taiwan
Department of Medicine, Mackay Medical College, New Taipei City 25245, Taiwan
Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 80708, Taiwan
Biodiversity Research Center, Academia Sinica, Taipei 11529, Taiwan
Institute of Marine Biology and Center of Excellence for the Oceans, National Taiwan Ocean University, Keelung 20224, Taiwan
Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, Taichung 40447, Taiwan
Department of Biotechnology, Asia University, Taichung 41354, Taiwan
Chinese Medical Research Center, China Medical University, Taichung 40447, Taiwan
Institute of Fisheries Science, National Taiwan University, Taipei 10617, Taiwan
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Mar. Drugs 2020, 18(6), 303;
Received: 9 May 2020 / Revised: 26 May 2020 / Accepted: 4 June 2020 / Published: 6 June 2020
Agar-based disc diffusion antimicrobial assay has shown that the ethyl acetate extract of the fermented broth of Aspergillus giganteus NTU967 isolated from Ulva lactuca exhibited significant antimicrobial activity in our preliminary screening of bioactive fungal strains. Therefore, column chromatography of the active principles from liquid- and solid–state fermented products of the fungal strain was carried out, and which had led to isolation of eleven compounds. Their structures were determined by spectral analysis to be seven new highly oxygenated polyketides, namely aspergilsmins A–G (17), along with previously reported patulin, deoxytryptoquivaline, tryptoquivaline and quinadoline B. Among these, aspergilsmin C (3) and patulin displayed promising anticancer activities against human hepatocellular carcinoma SK-Hep-1 cells and prostate cancer PC-3 cells with IC50 values between 2.7–7.3 μM. Furthermore, aspergilsmin C (3) and patulin exhibited significant anti-angiogenic functions by impeding cell growth and tube formation of human endothelial progenitor cells without any cytotoxicity. View Full-Text
Keywords: Aspergillus giganteus; Trichocomaceae; bioactive natural products; Polyketides; aspergilsmin Aspergillus giganteus; Trichocomaceae; bioactive natural products; Polyketides; aspergilsmin
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Chen, J.-J.; Wang, S.-W.; Chiang, Y.-R.; Pang, K.-L.; Kuo, Y.-H.; Shih, T.-Y.; Lee, T.-H. Highly Oxygenated Constituents from a Marine Alga-Derived Fungus Aspergillus giganteus NTU967. Mar. Drugs 2020, 18, 303.

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