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Extracts and Marine Algae Polysaccharides in Therapy and Prevention of Inflammatory Diseases of the Intestine

1
Somov Institute of Epidemiology and Microbiology, Vladivostok 690087, Russia
2
School of Biomedicine, Far Eastern Federal University, Vladivostok 690087, Russia
3
G.B. Elyakov Pacific Institute of Bioorganic Chemistry, FEB RAS, Vladivostok 690022, Russia
*
Author to whom correspondence should be addressed.
Mar. Drugs 2020, 18(6), 289; https://doi.org/10.3390/md18060289
Received: 28 April 2020 / Revised: 27 May 2020 / Accepted: 27 May 2020 / Published: 31 May 2020
Inflammatory bowel disease (IBD) is a serious public health problem worldwide. Current therapeutic strategies that use anti-inflammatory drugs, immunosuppressants, and biological treatments are often ineffective and have adverse health effects. In this regard, the use of natural compounds aimed at key pathogenic therapeutic targets in IBD attracts universal attention. Seaweed is a valuable source of structurally diverse biologically active compounds. The materials presented in the review indicate that seaweed extracts and polysaccharides are effective candidates for the development of drugs, biological food additives, and functional nutrition products for the treatment and prevention of IBD. The structural features of algal polysaccharides provide the possibility of exposure to therapeutic targets of IBD, including proinflammatory cytokines, chemokines, adhesion molecules, nuclear factor NF-kB, intestinal epithelial cells, reactive oxygen and nitrogen. Further study of the relationship between the effect of polysaccharides from different types of algae, with different structure and molecular weights on immune and epithelial cells, intestinal microorganisms will contribute to a deeper understanding of their mechanisms and will help in the development of drugs, dietary supplements, functional foods for the treatment of patients with IBD. View Full-Text
Keywords: inflammatory bowel disease; Crohn’s disease; ulcerative colitis; marine algae polysaccharides inflammatory bowel disease; Crohn’s disease; ulcerative colitis; marine algae polysaccharides
MDPI and ACS Style

Besednova, N.N.; Zaporozhets, T.S.; Kuznetsova, T.A.; Makarenkova, I.D.; Kryzhanovsky, S.P.; Fedyanina, L.N.; Ermakova, S.P. Extracts and Marine Algae Polysaccharides in Therapy and Prevention of Inflammatory Diseases of the Intestine. Mar. Drugs 2020, 18, 289.

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