Chitosan Oligosaccharide Fluorinated Derivative Control Root-Knot Nematode (Meloidogyne incognita) Disease Based on the Multi-Efficacy Strategy
by
Zhaoqian Fan 1,2, Yukun Qin 1,2,*, Song Liu 1,2, Ronge Xing 1,2, Huahua Yu 1,2 and Pengcheng Li 1,2,*
Zhaoqian Fan 1,2, Yukun Qin 1,2,*, Song Liu 1,2, Ronge Xing 1,2, Huahua Yu 1,2 and Pengcheng Li 1,2,*
1
Key Laboratory of Experimental Marine Biology, Center for Ocean Mega-Science, Institute of Oceanology, Chinese Academy of Sciences, No. 7 Nanhai Road, Qingdao 266071, China
2
Laboratory for Marine Drugs and Bioproducts, Pilot National Laboratory for Marine Science and Technology (Qingdao), No. 1 Wenhai Road, Qingdao 266237, China
*
Authors to whom correspondence should be addressed.
Mar. Drugs 2020, 18(5), 273; https://doi.org/10.3390/md18050273
Received: 25 April 2020 / Revised: 12 May 2020 / Accepted: 18 May 2020 / Published: 22 May 2020
Plant root-knot nematode disease is a great agricultural problem and commercially available nematicides have the disadvantages of high toxicity and limited usage; thus, it is urgent to develop new nematicides derived from nature substances. In this study, a novel fluorinated derivative was synthesized by modifying chitosan oligosaccharide (COS) using the strategy of multiple functions. The derivatives were characterized by FTIR, NMR, elemental analysis, and TG/DTG. The activity assays show that the derivatives can effectively kill the second instar larvae of Meloidogyne incognita in vitro, among them, chitosan-thiadiazole-trifluorobutene (COSSZFB) perform high eggs hatching inhibitory activity. The derivatives can regulate plant growth (photosynthetic pigment), improve immunity (chitinase and β-1,3-glucanase), and show low cytotoxicity and phytotoxicity. According to the multi-functional activity, the derivatives exhibit a good control effect on plant root-knot nematode disease in vivo. The results demonstrate that the COS derivatives (especially fluorinated derivative) perform multiple activities and show the potential to be further evaluated as nematicides.
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Keywords:
chitosan oligosaccharide (COS); modification; Meloidogyne incognita; multi-efficacy; nematicide
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
MDPI and ACS Style
Fan, Z.; Qin, Y.; Liu, S.; Xing, R.; Yu, H.; Li, P. Chitosan Oligosaccharide Fluorinated Derivative Control Root-Knot Nematode (Meloidogyne incognita) Disease Based on the Multi-Efficacy Strategy. Mar. Drugs 2020, 18, 273.
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