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Open AccessArticle

Bioactive Molecules from Mangrove Streptomyces qinglanensis 172205

Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, China
Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultura Sciences, Haikou 571101, China
Author to whom correspondence should be addressed.
Mar. Drugs 2020, 18(5), 255;
Received: 17 April 2020 / Revised: 12 May 2020 / Accepted: 12 May 2020 / Published: 13 May 2020
(This article belongs to the Special Issue Bioactive Molecules from Marine Microorganisms)
Five new compounds 15R-17,18-dehydroxantholipin (1), (3E,5E,7E)-3-methyldeca-3,5,7-triene-2,9-dione (2) and qinlactone A–C (35) were identified from mangrove Streptomyces qinglanensis 172205 with “genetic dereplication,” which deleted the highly expressed secondary metabolite-enterocin biosynthetic gene cluster. The chemical structures were established by spectroscopic methods, and the absolute configurations were determined by electronic circular dichroism (ECD). Compound 1 exhibited strong anti-microbial and antiproliferative bioactivities, while compounds 24 showed weak antiproliferative activities. View Full-Text
Keywords: mangrove Streptomyces; genetic dereplication; anti-microbial; antiproliferative mangrove Streptomyces; genetic dereplication; anti-microbial; antiproliferative
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MDPI and ACS Style

Xu, D.; Tian, E.; Kong, F.; Hong, K. Bioactive Molecules from Mangrove Streptomyces qinglanensis 172205. Mar. Drugs 2020, 18, 255.

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