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Open AccessArticle

Bioactive Molecules from Mangrove Streptomyces qinglanensis 172205

1
Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, China
2
Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultura Sciences, Haikou 571101, China
*
Author to whom correspondence should be addressed.
Mar. Drugs 2020, 18(5), 255; https://doi.org/10.3390/md18050255
Received: 17 April 2020 / Revised: 12 May 2020 / Accepted: 12 May 2020 / Published: 13 May 2020
(This article belongs to the Special Issue Bioactive Molecules from Marine Microorganisms)
Five new compounds 15R-17,18-dehydroxantholipin (1), (3E,5E,7E)-3-methyldeca-3,5,7-triene-2,9-dione (2) and qinlactone A–C (35) were identified from mangrove Streptomyces qinglanensis 172205 with “genetic dereplication,” which deleted the highly expressed secondary metabolite-enterocin biosynthetic gene cluster. The chemical structures were established by spectroscopic methods, and the absolute configurations were determined by electronic circular dichroism (ECD). Compound 1 exhibited strong anti-microbial and antiproliferative bioactivities, while compounds 24 showed weak antiproliferative activities. View Full-Text
Keywords: mangrove Streptomyces; genetic dereplication; anti-microbial; antiproliferative mangrove Streptomyces; genetic dereplication; anti-microbial; antiproliferative
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MDPI and ACS Style

Xu, D.; Tian, E.; Kong, F.; Hong, K. Bioactive Molecules from Mangrove Streptomyces qinglanensis 172205. Mar. Drugs 2020, 18, 255.

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