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Open AccessArticle

Cytotoxic Scalarane Sesterterpenes from the Sponge Hyrtios erectus

1
Natural Products Research Institute, College of Pharmacy, Seoul National University, San 56-1, Sillim, Gwanak, Seoul 151-742, Korea
2
Department of Agricultural Biotechnology, College of Agriculture and Life Science, Seoul National University, San 56-1, Sillim, Gwanak, Seoul 151-921, Korea
3
Department of Biological Sciences, College of Life Science and Nano Technology, Hannam University, 461-6 Jeonmin, Yuseong, Daejeon 305-811, Korea
*
Authors to whom correspondence should be addressed.
Mar. Drugs 2020, 18(5), 253; https://doi.org/10.3390/md18050253
Received: 7 April 2020 / Revised: 8 May 2020 / Accepted: 11 May 2020 / Published: 13 May 2020
(This article belongs to the Special Issue Terpenoids from Marine Organisms II)
Twelve new sesterterpenes along with eight known sesterterpenes were isolated from the marine sponge Hyrtios erectus collected off the coast of Chuuk Island, the Federated State of Micronesia. Based upon a combination of spectroscopic and computational analyses, these compounds were determined to be eight glycine-bearing scalaranes (18), a 3-keto scalarane (9), two oxidized-furan-bearing scalaranes (10 and 11), and a salmahyrtisane (12). Several of these compounds exhibited weak antiproliferation against diverse cancer cell lines as well as moderate anti-angiogenesis activities. The antiproliferative activity of new compound 4 was found to be associated with G0/G1 arrest in the cell cycle. View Full-Text
Keywords: sponge; Hyrtios erectus; sesterterpenes; scalaranes; antiproliferative sponge; Hyrtios erectus; sesterterpenes; scalaranes; antiproliferative
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MDPI and ACS Style

Kwon, O.-S.; Kim, D.; Kim, C.-K.; Sun, J.; Sim, C.J.; Oh, D.-C.; Lee, S.K.; Oh, K.-B.; Shin, J. Cytotoxic Scalarane Sesterterpenes from the Sponge Hyrtios erectus. Mar. Drugs 2020, 18, 253.

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