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Open AccessArticle

Clavukoellians G–K, New Nardosinane and Aristolane Sesquiterpenoids with Angiogenesis Promoting Activity from the Marine Soft Coral Lemnalia sp.

by Qi Wang 1,2,4,†, Xuli Tang 3,†, Hui Liu 1,2, Xiangchao Luo 1,2, Ping Jyun Sung 5,6, Pinglin Li 1,2,* and Guoqiang Li 1,2,*
1
Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China
2
Laboratory of Marine Drugs and Biological Products, National Laboratory for Marine Science and Technology, Qingdao 266235, China
3
College of Chemistry and Chemical Engineering, Ocean University of China, Qingdao 266100, China
4
Institutes of Chronic Disease, Qingdao University, Qingdao 266003, China
5
National Museum of Marine Biology and Aquarium, Pingtung 94450, Taiwan
6
Graduate Institute of Marine Biology, National Dong Hwa University, Pingtung 94450, Taiwan
*
Authors to whom correspondence should be addressed.
The authors contributed equally to this work.
Mar. Drugs 2020, 18(3), 171; https://doi.org/10.3390/md18030171
Received: 30 January 2020 / Revised: 9 March 2020 / Accepted: 11 March 2020 / Published: 20 March 2020
The chemical examination of the marine soft coral Lemnalia sp., collected at the Xisha islands in the South China Sea, resulted in the isolation of four new nardosinane-type sesquiterpenoids, namely clavukoellians G–J (14), and one new aristolane sesquiterpene, namely clavukoellian K (5), together with five known compounds, 610. The structure elucidation of the isolated natural products was based on various spectroscopic techniques including HRESIMS and NMR, while their absolute configurations were resolved on the basis of comparisons of the ECD spectra with the calculated ECD data. The isolated new compounds 15 were evaluated for their anti- and pro- angiogenesis activities in a transgenic fluorescent zebrafish (Tg(vegfr2:GFP)) model. Quantitative analysis revealed that compound 5 displayed pro-angiogenesis activity in a PTK787-induced vascular injury zebrafish model at 2.5 μM. Data showed that compound 5 significantly promoted the angiogenesis in a dose-dependent manner. View Full-Text
Keywords: Lemnalia sp.; clavukoellian; nardosinane; aristolane; sesquiterpenoid; angiogenesis promoting activity Lemnalia sp.; clavukoellian; nardosinane; aristolane; sesquiterpenoid; angiogenesis promoting activity
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MDPI and ACS Style

Wang, Q.; Tang, X.; Liu, H.; Luo, X.; Sung, P.J.; Li, P.; Li, G. Clavukoellians G–K, New Nardosinane and Aristolane Sesquiterpenoids with Angiogenesis Promoting Activity from the Marine Soft Coral Lemnalia sp.. Mar. Drugs 2020, 18, 171.

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