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Open AccessArticle

New Eunicellin-Type Diterpenes from the Panamanian Octocoral Briareum asbestinum

1
Centro de Biodiversidad y Descubrimiento de Drogas, Instituto de Investigaciones Científicas y Servicios de Alta Tecnología (INDICASAT AIP), Panamá, Apartado 0843-01103, Republic of Panama
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Smithsonian Tropical Research Institute, Balboa, Ancon, P. O. Box 0843-03092, Republic of Panama
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Department of Biochemistry and Biotechnology, Faculty of Chemistry, Universitat Rovira i Virgili, 43007 Tarragona, Spain
4
Department of Pharmacology, Faculty of Pharmacy, University of Seville, 41012 Seville, Spain
*
Authors to whom correspondence should be addressed.
Mar. Drugs 2020, 18(2), 84; https://doi.org/10.3390/md18020084
Received: 27 December 2019 / Revised: 22 January 2020 / Accepted: 24 January 2020 / Published: 27 January 2020
Gorgonian octocorals are considered a prolific source of secondary metabolites with a wide range of biological activities, including anti-inflammatory activity. In particular, the genus Briareum is known for producing a wealth of diterpenes with complex chemical structures. The chemical study of the methanolic extract of Briareum asbestinum collected in Bocas del Toro, on the Caribbean side of Panama, led to the isolation of three new eunicellin-type diterpenes: briarellin T (1), asbestinin 27 (2), asbestinin 28 (3) and the previously described asbestinin 17 (4). The structures of the new compounds were determined by extensive NMR analyses and HRMS. Anti-inflammatory activity assays showed a significant reduction of the pro-inflammatory cytokines TNF-α, IL-6, IL-1β and IL-8 as well as a downregulation of COX-2 expression in LPS-stimulated THP-1 macrophages. These findings support the potential use of these marine compounds as therapeutic agents in the treatment of inflammatory diseases. View Full-Text
Keywords: asbestinins; briarellins; eunicellin diterpenes; Briareum; cytokines; cyclooxygenase-2 asbestinins; briarellins; eunicellin diterpenes; Briareum; cytokines; cyclooxygenase-2
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Gutiérrez, M.; Santamaría, R.; Gómez-Reyes, J.F.; Guzmán, H.M.; Ávila-Román, J.; Motilva, V.; Talero, E. New Eunicellin-Type Diterpenes from the Panamanian Octocoral Briareum asbestinum. Mar. Drugs 2020, 18, 84.

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