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Design and Synthesis of Anti-Cancer Chimera Molecules Based on Marine Natural Products

College of Pharmacy and Research Institute of Pharmaceutical Sciences, Gyeongsang National University, Jinju Daero 501, Jinju 52828, Gyeongnam, Korea
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Mar. Drugs 2019, 17(9), 500; https://doi.org/10.3390/md17090500
Received: 23 July 2019 / Revised: 7 August 2019 / Accepted: 16 August 2019 / Published: 27 August 2019
(This article belongs to the Collection Marine Compounds and Cancer)
In this paper, the chemical conjugation of marine natural products with other bioactive molecules for developing an advanced anti-cancer agent is described. Structural complexity and the extraordinary biological features of marine natural products have led to tremendous research in isolation, structural elucidation, synthesis, and pharmacological evaluation. In addition, this basic scientific achievement has made it possible to hybridize two or more biologically important skeletons into a single compound. The hybridization strategy has been used to identify further opportunities to overcome certain limitations, such as structural complexity, scarcity problems, poor solubility, severe toxicity, and weak potency of marine natural products for advanced development in drug discovery. Further, well-designed marine chimera molecules can function as a platform for target discovery or degradation. In this review, the design, synthesis, and biological evaluation of recent marine chimera molecules are presented. View Full-Text
Keywords: chimera; chemical conjugation; marine natural products; anticancer agent; hybridization chimera; chemical conjugation; marine natural products; anticancer agent; hybridization
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MDPI and ACS Style

Ha, M.W.; Song, B.R.; Chung, H.J.; Paek, S.-M. Design and Synthesis of Anti-Cancer Chimera Molecules Based on Marine Natural Products. Mar. Drugs 2019, 17, 500.

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