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The Purification, Characterization, and Biological Activity of New Polyketides from Mangrove-Derived Endophytic Fungus Epicoccum nigrum SCNU-F0002

1
School of Chemistry and Environment, South China Normal University, Guangzhou 510006, China
2
School of Chemistry, Sun Yat-Sen University, Guangzhou 510275, China
*
Author to whom correspondence should be addressed.
Mar. Drugs 2019, 17(7), 414; https://doi.org/10.3390/md17070414
Received: 19 May 2019 / Revised: 6 July 2019 / Accepted: 9 July 2019 / Published: 12 July 2019
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Abstract

Six new polyketides, including one coumarin (1), two isocoumarins (2 and 3), dihydroradicinin (4), and two benzofuranone derivatives (7 and 8), together with seven known analogues (56 and 913) were isolated from the culture of the mangrove endophytic fungus Epicoccum nigrum SCNU-F0002. The structures were elucidated on the interpretation of spectroscopic data. The absolute configuration of Compounds 2 and 3 were determined by comparison of their ECD spectra with the data of their analogue dihydroisocoumarins described in the literature. The absolute configuration of 4 was determined by single-crystal X-ray diffraction. All the compounds were screened for their antioxidant, antibacterial, anti-phytopathogenic fungi and cytotoxic activities. Using a DPPH radical-scavenging assay, Compounds 1013 showed potent antioxidant activity with IC50 values of 13.6, 12.1, 18.1, and 11.7 μg/mL, respectively. In addition, Compounds 6 and 7 showed antibacterial effects against Bacillus subtilis (ATCC 6538), Escherichia coli (ATCC 8739), and Staphylococcus aureus (ATCC 6538), with MIC values in the range of 25–50 μg/mL. View Full-Text
Keywords: benzofuranone derivative; coumarin; dihydroradicinin; antioxidant activity; antibacterial effect benzofuranone derivative; coumarin; dihydroradicinin; antioxidant activity; antibacterial effect
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Yan, Z.; Wen, S.; Ding, M.; Guo, H.; Huang, C.; Zhu, X.; Huang, J.; She, Z.; Long, Y. The Purification, Characterization, and Biological Activity of New Polyketides from Mangrove-Derived Endophytic Fungus Epicoccum nigrum SCNU-F0002. Mar. Drugs 2019, 17, 414.

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