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Recent Advances in Chitosan-Based Carriers for Gene Delivery

School of Materials Science & Engineering, Nanyang Technological University, Singapore 639798, Singapore
*
Author to whom correspondence should be addressed.
Contributed equally.
Mar. Drugs 2019, 17(6), 381; https://doi.org/10.3390/md17060381
Received: 28 May 2019 / Revised: 17 June 2019 / Accepted: 22 June 2019 / Published: 25 June 2019
(This article belongs to the Special Issue Marine Biopolymers and Drug Delivery)
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Abstract

Approximately 4000 diseases are associated with malfunctioning genes in a particular cell type. Gene-based therapy provides a platform to modify the disease-causing genes expression at the cellular level to treat pathological conditions. However, gene delivery is challenging as these therapeutic genes need to overcome several physiological and intracellular barriers in order, to reach the target cells. Over the years, efforts have been dedicated to develop efficient gene delivery vectors to overcome these systemic barriers. Chitosan, a versatile polysaccharide, is an attractive non-viral vector material for gene delivery mainly due to its cationic nature, biodegradability and biocompatibility. The present review discusses the design factors that are critical for efficient gene delivery/transfection and highlights the recent progress of gene therapy using chitosan-based carriers. View Full-Text
Keywords: chitosan; siRNA; DNA; gene delivery; nanoparticles; polyplex; complex; nucleic acid delivery; sustained- release; gene knock-down; gene therapy chitosan; siRNA; DNA; gene delivery; nanoparticles; polyplex; complex; nucleic acid delivery; sustained- release; gene knock-down; gene therapy
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Cao, Y.; Tan, Y.F.; Wong, Y.S.; Liew, M.W.J.; Venkatraman, S. Recent Advances in Chitosan-Based Carriers for Gene Delivery. Mar. Drugs 2019, 17, 381.

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