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In Vitro Studies Reveal Antiurolithic Effect of Antioxidant Sulfated Polysaccharides from the Green Seaweed Caulerpa cupressoides var flabellata

1
Laboratory of Natural Polymer Biotechnology (BIOPOL), Department of Biochemistry, Center of Biosciences, Federal University of Rio Grande do Norte (UFRN), Natal, Rio Grande do Norte- RN 59078-970, Brazil
2
Federal Institute of Education, Science and Technology of Piauí (IFPI), São Raimundo Nonato Campus, São Raimundo Nonato-PI 64.770-000, Brazil
3
State University of Rio Grande do Norte (UERN), Mossoró-RN 59.610-210, Brazil
4
Federal Institute of Education, Science and Technology of Rio Grande do Norte (IFRN), João Câmara-RN 59.550-000, Brazil
5
Federal Institute of Education, Science and Technology of Rio Grande do Norte (IFRN), Canguaretama-RN 59.190-000, Brazil
*
Author to whom correspondence should be addressed.
Mar. Drugs 2019, 17(6), 326; https://doi.org/10.3390/md17060326
Received: 31 March 2019 / Revised: 29 April 2019 / Accepted: 30 April 2019 / Published: 1 June 2019
(This article belongs to the Special Issue Pre-Clinical Marine Drug Discovery)
Urolithiasis affects approximately 10% of the world population and is strongly associated with calcium oxalate (CaOx) crystals. Currently, there is no efficient compound that can be used to prevent this disease. However, seaweeds’ sulfated polysaccharides (SPs) can change the CaOx crystals surface’s charge and thus modify the crystallization dynamics, due to the interaction of the negative charges of these polymers with the crystal surface during their synthesis. We observed that the SPs of Caulerpa cupressoides modified the morphology, size and surface charge of CaOx crystals. Thus, these crystals became similar to those found in healthy persons. In the presence of SPs, dihydrate CaOx crystals showed rounded or dumbbell morphology. Infrared analysis, fluorescence microscopy, flow cytometry (FITC-conjugated SPs) and atomic composition analysis (EDS) allowed us to propose the mode of action between the Caulerpa’s SPs and the CaOx crystals. This study is the first step in understanding the interactions between SPs, which are promising molecules for the treatment of urolithiasis, and CaOx crystals, which are the main cause of kidney stones. View Full-Text
Keywords: urolithiasis; green algae; COD dumbbell; COD stabilization urolithiasis; green algae; COD dumbbell; COD stabilization
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Gomes, D.L.; Melo, K.R.T.; Queiroz, M.F.; Batista, L.A.N.C.; Santos, P.C.; Costa, M.S.S.P.; Almeida-Lima, J.; Camara, R.B.G.; Costa, L.S.; Rocha, H.A.O. In Vitro Studies Reveal Antiurolithic Effect of Antioxidant Sulfated Polysaccharides from the Green Seaweed Caulerpa cupressoides var flabellata. Mar. Drugs 2019, 17, 326.

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