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Open AccessReview

Antimicrobial and Immunomodulatory Properties and Applications of Marine-Derived Proteins and Peptides

1
Department of Biomedical Science, Chosun University, Gwangju 501-759, Korea
2
Department of Convergences, Kongju National University, Kongju 314-701, Korea
3
Research Center for Proteineous Materials, Chosun University, Gwangju 501-759, Korea
*
Author to whom correspondence should be addressed.
Mar. Drugs 2019, 17(6), 350; https://doi.org/10.3390/md17060350
Received: 2 May 2019 / Revised: 3 June 2019 / Accepted: 4 June 2019 / Published: 12 June 2019
(This article belongs to the Special Issue Marine Immunomodulators)
Marine organisms provide an abundant source of potential medicines. Many of the marine-derived biomaterials have been shown to act as different mechanisms in immune responses, and in each case they can significantly control the immune system to produce effective reactions. Marine-derived proteins, peptides, and protein hydrolysates exhibit various physiologic functions, such as antimicrobial, anticancer, antioxidant, antihypertensive, and anti-inflammatory activities. Recently, the immunomodulatory properties of several antimicrobial peptides have been demonstrated. Some of these peptides directly kill bacteria and exhibit a variety of immunomodulatory activities that improve the host innate immune response and effectively eliminate infection. The properties of immunomodulatory proteins and peptides correlate with their amino acid composition, sequence, and length. Proteins and peptides with immunomodulatory properties have been tested in vitro and in vivo, and some of them have undergone different clinical and preclinical trials. This review provides a comprehensive overview of marine immunomodulatory proteins, peptides, and protein hydrolysates as well as their production, mechanisms of action, and applications in human therapy. View Full-Text
Keywords: marine organism; immunomodulatory peptide; protein hydrolysates; immune response marine organism; immunomodulatory peptide; protein hydrolysates; immune response
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Kang, H.K.; Lee, H.H.; Seo, C.H.; Park, Y. Antimicrobial and Immunomodulatory Properties and Applications of Marine-Derived Proteins and Peptides. Mar. Drugs 2019, 17, 350.

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