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Divergolides T–W with Apoptosis-Inducing Activity from the Mangrove-Derived Actinomycete Streptomyces sp. KFD18

College of Life Science, Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of Ministry of Education, Hebei University, Baoding 071002, China
Hainan Key Laboratory for Research and Development of Natural Product from Li Folk Medicine, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China
Guangdong Provincial Key Laboratory of Marine Biotechnology, Department of Biology, Shantou University, Shantou 515063, China
Authors to whom correspondence should be addressed.
These authors contributed equally to this paper.
Mar. Drugs 2019, 17(4), 219;
Received: 19 March 2019 / Revised: 5 April 2019 / Accepted: 8 April 2019 / Published: 11 April 2019
(This article belongs to the Collection Marine Compounds and Cancer)
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Four new ansamycins, named divergolides T–W (14), along with two known analogs were isolated from the fermentation broth of the mangrove-derived actinomycete Streptomyces sp. KFD18. The structures of the compounds, including the absolute configurations of their stereogenic carbons, were determined by spectroscopic data and single-crystal X-ray diffraction analysis. Compounds 14 showed cytotoxic activity against the human gastric cancer cell line SGC-7901, the human leukemic cell line K562, the HeLa cell line, and the human lung carcinoma cell line A549, with 1 being the most active while compounds 5 and 6 were inactive against all the tested cell lines. Compounds 1 and 3 showed very potent and specific cytotoxic activities (IC50 2.8 and 4.7 µM, respectively) against the SGC-7901 cells. Further, the apoptosis-inducing effect of 1 and 3 against SGC-7901 cells was demonstrated by two kinds of staining methods for the first time. View Full-Text
Keywords: mangrove-derived actinomycete; ansamycins; divergolides; apoptosis-inducing activity mangrove-derived actinomycete; ansamycins; divergolides; apoptosis-inducing activity

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Zhou, L.-M.; Kong, F.-D.; Xie, Q.-Y.; Ma, Q.-Y.; Hu, Z.; Zhao, Y.-X.; Luo, D.-Q. Divergolides T–W with Apoptosis-Inducing Activity from the Mangrove-Derived Actinomycete Streptomyces sp. KFD18. Mar. Drugs 2019, 17, 219.

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