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Mar. Drugs 2019, 17(3), 160; https://doi.org/10.3390/md17030160

Complex Relationships between the Blue Pigment Marennine and Marine Bacteria of the Genus Vibrio

1
Laboratoire Mer Molécule Santé (EA 2160, FR CNRS 3473 IUML), Le Mans Université, 72000 Le Mans, France
2
Ifremer, Unité Physiologie Fonctionnelle des Organismes Marins, ZI de la Pointe du Diable, 29280 Plouzané, France
3
Sorbonne Université (UPMC Paris 06, CNRS, UMR 8227) Laboratoire de Biologie Intégrative des Modèles Marins, Station Biologique de Roscoff, 29680 Roscoff, France
4
Ifremer (RBE-SG2M-LGPMM) Laboratoire de Génétique et de Pathologie des Mollusques Marins, Station La Tremblade, Avenue Mus Loup, F-17390 La Tremblade, France
*
Author to whom correspondence should be addressed.
Received: 14 February 2019 / Revised: 28 February 2019 / Accepted: 4 March 2019 / Published: 8 March 2019
(This article belongs to the Special Issue Marine Bacteria as Sources of Bioactive Compounds)
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Abstract

Marennine, the water-soluble blue pigment produced by the marine diatom Haslea ostrearia, is known to display antibacterial activities. Previous studies have demonstrated a prophylactic effect of marennine on bivalve larvae challenged with a pathogenic Vibrio splendidus, suggesting that the blue Haslea is a good candidate for applications in aquaculture as a source of a natural antimicrobial agent. Indeed, the genus Vibrio is ubiquitous in aquaculture ecosystems, and regular events of pathogenic invasion cause some of the biggest losses worldwide. To better characterize the effects of marennine on Vibrios, a panel of 30 Vibrio strains belonging to 10 different species was tested, including bivalve pathogenic species (e.g., Vibrio crassostreae and Vibrio harveyi). Vibrio strains were first exposed to 10 and 25 µg mL−1 of Blue Water (BW), a concentrated culture supernatant of H. ostrearia containing marennine. This screening evidenced a great diversity in responses, from growth stimulation to a total inhibition, at both the interspecific or intraspecific level. In a second series of experiments, 10 Vibrio strains were exposed to BW at concentrations ranging from 5 to 80 µg mL−1. The highest concentrations of BW did not systematically result in the highest growth inhibition as hormetic responses—opposite effects regarding the concentration—were occasionally evidenced. The relationships between marennine and Vibrio strains appear more complex than expected and justify further study—in particular, on the mechanisms of action—before considering applications as a natural prophylactic or antibiotic agent in aquaculture. View Full-Text
Keywords: antibacterial activity; diauxie; Haslea; hormesis; marennine; Vibrio antibacterial activity; diauxie; Haslea; hormesis; marennine; Vibrio
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Falaise, C.; James, A.; Travers, M.-A.; Zanella, M.; Badawi, M.; Mouget, J.-L. Complex Relationships between the Blue Pigment Marennine and Marine Bacteria of the Genus Vibrio. Mar. Drugs 2019, 17, 160.

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