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Open AccessArticle

Testing the Neuroprotective Properties of PCSO-524® Using a Neuronal Cell Cycle Suppression Assay

Division of Life Science, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China
*
Author to whom correspondence should be addressed.
Mar. Drugs 2019, 17(2), 79; https://doi.org/10.3390/md17020079
Received: 23 December 2018 / Revised: 20 January 2019 / Accepted: 21 January 2019 / Published: 24 January 2019
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Abstract

Cell cycle reentry is a unified mechanism shared by several neurodegenerative diseases, including Alzheimer’s disease (AD) and Ataxia Telangiectasia (A-T). This phenotype is often related to neuroinflammation in the central nervous system. To mimic brain inflammation in vitro, we adopted the previously established method of using conditioned medium collected from activated THP-1 cells and applied it to both differentiated HT22 cells and primary neurons. Unscheduled cell cycle events were observed in both systems, indicating the potential of this approach as an in vitro model of neurodegenerative disease. We used this assay to measure the neuroprotective effects of New Zealand green-lipped mussel extract, PCSO-524®, to protect post-mitotic cells from cell cycle reentry. We found that, both in vitro and in an animal model, PCSO-524® displayed promising neuroprotective effects, and thus has potential to postpone or prevent the onset of neurodegenerative disease. View Full-Text
Keywords: PCSO-524®; neuroinflammation; neuronal cell cycle event; neuroprotection; Alzheimer’s disease PCSO-524®; neuroinflammation; neuronal cell cycle event; neuroprotection; Alzheimer’s disease
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Zhu, B.; Zhang, Y.; Herrup, K. Testing the Neuroprotective Properties of PCSO-524® Using a Neuronal Cell Cycle Suppression Assay. Mar. Drugs 2019, 17, 79.

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