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Mar. Drugs 2019, 17(2), 100; https://doi.org/10.3390/md17020100

New Acyclic Cytotoxic Jasplakinolide Derivative from the Marine Sponge Jaspis splendens

1
Institute of Pharmaceutical Biology and Biotechnology, Heinrich-Heine University, Universitaetsstrasse 1, D-40225 Duesseldorf, Germany
2
Department of Pharmacognosy, Faculty of Pharmacy, Ain-Shams University, Abbasia, Cairo 11566, Egypt
3
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Mu’tah University, Al-Karak 61710, Jordan
4
Institute of Physiological Chemistry, University Medical Center of the Johannes Gutenberg University Mainz, 55128 Mainz, Germany
5
State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100083, China
*
Authors to whom correspondence should be addressed.
Received: 16 January 2019 / Revised: 1 February 2019 / Accepted: 1 February 2019 / Published: 6 February 2019
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Abstract

A new acylic jasplakinolide congener (2), another acyclic derivative requiring revision (4), together with two jasplakinolide derivatives including the parent compound jasplakinolide (1) were isolated from the Indonesian marine sponge Jaspis splendens. The chemical structures of the new and known compounds were unambiguously elucidated based on HRESIMS and exhaustive 1D and 2D NMR spectral analysis as well as a comparison of their NMR data with those of jasplakinolide (1). The isolated jasplakinolides inhibited the growth of mouse lymphoma (L5178Y) cells in vitro with IC50 values in the low micromolar to nanomolar range. View Full-Text
Keywords: Jaspis splendens; jasplakinolide Z6; jasplakinolide Z5; cytotoxic activity Jaspis splendens; jasplakinolide Z6; jasplakinolide Z5; cytotoxic activity
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Ebada, S.S.; Müller, W.E.G.; Lin, W.; Proksch, P. New Acyclic Cytotoxic Jasplakinolide Derivative from the Marine Sponge Jaspis splendens. Mar. Drugs 2019, 17, 100.

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