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Open AccessArticle

Dietary Recombinant Phycoerythrin Modulates the Gut Microbiota of H22 Tumor-Bearing Mice

by Hongtao Qi 1,2, Ying Liu 3, Xin Qi 4, Hui Liang 5, Huaxin Chen 6,7,8, Peng Jiang 6,7,8,* and Dongfeng Wang 1,*
1
Laboratory of Food Chemistry and Nutrition, College of Food Science and Engineering, Ocean University of China, Qingdao 266003, China
2
Food Science and Engineering Department, College of Life Sciences, Qingdao University, Qingdao 266071, China
3
Laboratory of Cell and Molecular Biology, Basic Medical College, Qingdao University, Qingdao 266071, China
4
Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China
5
Department of Human Nutrition, College of Public Health, Qingdao University, Qingdao 266021, China
6
CAS Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China
7
Laboratory for Marine Biology and Biotechnology, Qingdao National Laboratory for Marine Science and Technology, Qingdao 266237, China
8
Centre for Ocean Mega-Science, Chinese Academy of Sciences, Qingdao 266071, China
*
Authors to whom correspondence should be addressed.
Mar. Drugs 2019, 17(12), 665; https://doi.org/10.3390/md17120665
Received: 3 September 2019 / Revised: 18 November 2019 / Accepted: 18 November 2019 / Published: 26 November 2019
(This article belongs to the Special Issue Marine Immunomodulators)
Normal intestinal flora is widely involved in many functions of the host: nutritional metabolism; maintenance of intestinal microecological balance; regulation of intestinal endocrine function and nerve signal transduction; promotion of intestinal immune system development and maturation; inhibition of pathogenic bacteria growth and colonization, reduction of its invasion to intestinal mucosa, and so on. In recent years, more and more studies have shown that intestinal flora is closely related to the occurrence, development, and treatment of various tumors. It is indicated that recombinant phycoerythrin (RPE) has significant anti-tumor and immunomodulatory effects. However, little is known about the mechanism of the effect of oral (or intragastric) administration of RPE on gut microbiota in tumor-bearing animals. In this study, using high-throughput 16S rDNA sequencing, we examined the response of gut microbiota in H22-bearing mice to dietary RPE supplementation. The results showed that the abundance of beneficial bacteria in the mice intestinal flora decreased and that of the detrimental flora increased after inoculation with tumor cells (H22); following treatment with dietary RPE, the abundance of beneficial bacteria in the intestinal flora significantly increased and that of detrimental bacteria decreased. In this study, for the first time, it was demonstrated that dietary RPE could modulate the gut microbiota of the H22 bearing mice by increasing the abundance of beneficial bacteria and decreasing that of detrimental bacteria among intestinal bacteria, providing evidence for the mechanism by which bioactive proteins affect intestinal nutrition and disease resistance in animals. View Full-Text
Keywords: recombinant phycoerythrin; anti-tumor and immunomodulatory effects; intestinal flora; high-throughput sequencing; microbial barrier recombinant phycoerythrin; anti-tumor and immunomodulatory effects; intestinal flora; high-throughput sequencing; microbial barrier
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Qi, H.; Liu, Y.; Qi, X.; Liang, H.; Chen, H.; Jiang, P.; Wang, D. Dietary Recombinant Phycoerythrin Modulates the Gut Microbiota of H22 Tumor-Bearing Mice. Mar. Drugs 2019, 17, 665.

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