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Current Research on the Bioprospection of Linear Diterpenes from Bifurcaria bifurcata: From Extraction Methodologies to Possible Applications

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CICECO-Aveiro Institute of Materials, Chemistry Department, University of Aveiro, 3810-193 Aveiro, Portugal
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QOPNA/LAQV & REQUIMTE, Chemistry Department, University of Aveiro, 3810-193 Aveiro, Portugal
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Author to whom correspondence should be addressed.
Mar. Drugs 2019, 17(10), 556; https://doi.org/10.3390/md17100556
Received: 23 August 2019 / Revised: 26 September 2019 / Accepted: 26 September 2019 / Published: 28 September 2019
Marine resources are considered as a very promising source of bioactive molecules, and macroalgae in particular have gained special attention, due to their structurally diverse composition. Particular interest has been devoted to the brown macroalga Bifurcaria bifurcata, due to their abundance in bioactive linear diterpenes. In this appraisal, a thorough review concerning the methodologies used in the extraction, fractionation, and identification of diterpenes from B. bifurcata is provided and discussed in detail. An exhaustive compilation of the mass spectra and nuclear magnetic resonance (NMR) data are also provided. The in vitro and in chemico assays already performed to assess different biological activities attributed to B. bifurcata diterpenes are also reviewed, emphasizing the use of isolated components, enriched fractions, or crude extracts. The associated major strengths and challenges for the exploitation of B. bifurcata diterpenes for high-value applications are critically discussed. View Full-Text
Keywords: Bifurcaria bifurcata; linear diterpenes; extraction; identification; biological activities; macroalgae; high value applications Bifurcaria bifurcata; linear diterpenes; extraction; identification; biological activities; macroalgae; high value applications
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MDPI and ACS Style

Pais, A.C.; Saraiva, J.A.; Rocha, S.M.; Silvestre, A.J.; Santos, S.A. Current Research on the Bioprospection of Linear Diterpenes from Bifurcaria bifurcata: From Extraction Methodologies to Possible Applications. Mar. Drugs 2019, 17, 556.

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